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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sdc-2  -  Protein SDC-2

Caenorhabditis elegans

 
 
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High impact information on sdc-2

  • Moreover, sdc-2, a gene that must be repressed by xol-1 to ensure male development, may be a direct target of negative regulation by xol-1 [1].
  • While the masculinization is blocked by mutations in sex determining genes required for male development (her-1 and fem-3), the lethality, dumpiness and overexpression of X-linked genes are not, indicating that the effect of sdc-2 mutations on sex determination and dosage compensation are ultimately implemented by two independent pathways [2].
  • Mutations in sdc-2 cause phenotypes that appear to result from a shift of both the sex determination and dosage compensation processes in XX animals to the XO modes of expression [2].
  • We have identified a new X-linked gene, sdc-2, that controls the hermaphrodite (XX) modes of both sex determination and X chromosome dosage compensation in Caenorhabditis elegans [2].

References

  1. xol-1 acts as an early switch in the C. elegans male/hermaphrodite decision. Rhind, N.R., Miller, L.M., Kopczynski, J.B., Meyer, B.J. Cell (1995) [Pubmed]
  2. The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals. Nusbaum, C., Meyer, B.J. Genetics (1989) [Pubmed]
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