The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

her-1  -  Protein HER-1

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on her-1

  • Evidence from mosaic analysis of the masculinizing gene her-1 for cell interactions in C. elegans sex determination [1].
  • The activity of the first gene in the sex-determining cascade, her-1, is required for male sexual development [1].
  • We show here that SDC-2 recruits the entire dosage compensation complex to her-1, directing this X-chromosome repression machinery to silence an individual, autosomal gene [2].
  • In XO animals, tra-2 is negatively regulated by her-1, which acts cell nonautonomously [3].
  • These results suggest that mag-1 interacts with the fog, fem, and gld genes and acts independently of her-1 [4].

Biological context of her-1

  • Mutations in her-1 are without effect on XX animals, but the her-2 mutation prevents sperm production in both XX and XO animals, in addition to its effect on the sexual phenotype of XO animals [5].
  • These two mutations may define a binding site for negative regulators of her-1 [6].
  • Evidence from experiments examining the effect of karyotype on recombination in males sexually transformed by the her-1 mutation into XO hermaphrodites (normally XX), suggests the sexual phenotype rather than genotype determines the recombination frequency characteristic of a particular sex [7].
  • We used these effects as an assay in a deletion analysis of the two her-1 promoter regions to define potential cis-regulatory sites required for the putative titration [8].
  • To identify conserved elements in her-1 we have cloned and characterized two homologous nematode genes: one by synteny from the closely related free-living species C. briggsae (Cb-her-1) and the other, starting with a fortuitously identified expressed sequence tag, from the distantly related parasite Brugia malayi (Bm-her-1) [9].

Other interactions of her-1

  • If so, then regulation of sexual fate by her-1 and tra-2 might provide a general model for the coordination of groups of cells to follow a single cell fate [3].
  • The levels of these transcripts are also elevated in XX animals carrying a loss-of-function mutation in either sdc-1 or sdc-2, consistent with the proposed roles of these genes as negative regulators of her-1 [10].
  • In XX hermaphrodites, accumulation of both her-1 transcripts is repressed by the sdc genes, which in turn are negatively regulated by the xol-1 gene [8].

Analytical, diagnostic and therapeutic context of her-1

  • Functional dissection of her-1 in vivo revealed DNA recognition elements required for SDC-2 binding, recruitment of the dosage compensation complex, and transcriptional repression [2].


  1. Evidence from mosaic analysis of the masculinizing gene her-1 for cell interactions in C. elegans sex determination. Hunter, C.P., Wood, W.B. Nature (1992) [Pubmed]
  2. A molecular link between gene-specific and chromosome-wide transcriptional repression. Chu, D.S., Dawes, H.E., Lieb, J.D., Chan, R.C., Kuo, A.F., Meyer, B.J. Genes Dev. (2002) [Pubmed]
  3. tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway. Kuwabara, P.E., Okkema, P.G., Kimble, J. Mol. Biol. Cell (1992) [Pubmed]
  4. mag-1, a homolog of Drosophila mago nashi, regulates hermaphrodite germ-line sex determination in Caenorhabditis elegans. Li, W., Boswell, R., Wood, W.B. Dev. Biol. (2000) [Pubmed]
  5. More sex-determination mutants of Caenorhabditis elegans. Hodgkin, J. Genetics (1980) [Pubmed]
  6. Sequenced alleles of the Caenorhabditis elegans sex-determining gene her-1 include a novel class of conditional promoter mutations. Perry, M.D., Trent, C., Robertson, B., Chamblin, C., Wood, W.B. Genetics (1994) [Pubmed]
  7. Sex-related differences in crossing over in Caenorhabditis elegans. Zetka, M.C., Rose, A.M. Genetics (1990) [Pubmed]
  8. Evidence for multiple promoter elements orchestrating male-specific regulation of the her-1 gene in Caenorhabditis elegans. Li, W., Streit, A., Robertson, B., Wood, W.B. Genetics (1999) [Pubmed]
  9. Homologs of the Caenorhabditis elegans masculinizing gene her-1 in C. briggsae and the filarial parasite Brugia malayi. Streit, A., Li, W., Robertson, B., Schein, J., Kamal, I.H., Marra, M., Wood, W.B. Genetics (1999) [Pubmed]
  10. Sex-specific transcriptional regulation of the C. elegans sex-determining gene her-1. Trent, C., Purnell, B., Gavinski, S., Hageman, J., Chamblin, C., Wood, W.B. Mech. Dev. (1991) [Pubmed]
WikiGenes - Universities