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Gene Review

flr-1  -  Protein FLR-1

Caenorhabditis elegans

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High impact information on flr-1

  • The flr-1 gene encodes a novel ion channel belonging to the DEG/ENaC (C. elegans degenerin and mammalian epithelial sodium channel) superfamily [1].
  • A flr-1::GFP (green fluorescent protein) fusion gene that can rescue the flr-1 mutant phenotypes is expressed only in the intestine from embryos to adults [1].
  • To elucidate the mechanism, we studied flr-1 mutants, which show very short defecation cycle periods [1].
  • Mutants in three of the genes (class 1 genes: flr-1 X, flr-3 IV, and flr-4 X) are resistant to 400 micrograms/ml NaF [2].


  1. An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans. Take-Uchi, M., Kawakami, M., Ishihara, T., Amano, T., Kondo, K., Katsura, I. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Isolation, characterization and epistasis of fluoride-resistant mutants of Caenorhabditis elegans. Katsura, I., Kondo, K., Amano, T., Ishihara, T., Kawakami, M. Genetics (1994) [Pubmed]
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