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Gene Review

mec-10  -  Protein MEC-10

Caenorhabditis elegans

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High impact information on degenerin

  • Mechanosensory transduction in touch receptor neurons is believed to be mediated by DEG/ENaC (degenerin/epithelial Na+ channel) proteins in nematodes and mammals [1].
  • In the nematode Caenorhabditis elegans, gain-of-function mutations in the degenerin genes mec-4 and mec-10 (denoted mec-4(d) and mec-10(d), respectively) cause degeneration of the touch cells [1].
  • A related mammalian gene, rat alpha-rENaC, induces an amiloride-sensitive Na+ current when introduced to Xenopus oocytes, strongly suggesting that degenerin genes encode ion channel proteins [2].
  • The flr-1 gene encodes a novel ion channel belonging to the DEG/ENaC (C. elegans degenerin and mammalian epithelial sodium channel) superfamily [3].
  • An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans [3].

Biological context of degenerin


Other interactions of degenerin


  1. The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Chelur, D.S., Ernstrom, G.G., Goodman, M.B., Yao, C.A., Chen, L., O' Hagan, R., Chalfie, M. Nature (2002) [Pubmed]
  2. A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Hong, K., Driscoll, M. Nature (1994) [Pubmed]
  3. An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans. Take-Uchi, M., Kawakami, M., Ishihara, T., Amano, T., Kondo, K., Katsura, I. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle. Jospin, M., Mariol, M.C., Segalat, L., Allard, B. J. Physiol. (Lond.) (2004) [Pubmed]
  5. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. Waldmann, R., Champigny, G., Voilley, N., Lauritzen, I., Lazdunski, M. J. Biol. Chem. (1996) [Pubmed]
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