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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sad-1  -  Protein SAD-1

Caenorhabditis elegans

 
 
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High impact information on sad-1

  • Overexpression of SAD-1 causes mislocalization of vesicle proteins to dendrites, suggesting that sad-1 affects axonal-dendritic polarity as well as synaptic development [1].
  • In sad-1 mutant animals presynaptic vesicle clusters in sensory neurons and motor neurons are diffuse and disorganized [1].
  • We show that sad-1 and nab-1 function in the same genetic pathway to restrict axonal fate [2].

References

  1. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. Crump, J.G., Zhen, M., Jin, Y., Bargmann, C.I. Neuron (2001) [Pubmed]
  2. Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans. Hung, W., Hwang, C., Po, M.D., Zhen, M. Development (2007) [Pubmed]
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