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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nxn  -  nucleoredoxin

Mus musculus

Synonyms: Gn25, Nucleoredoxin, Protein Red-1, l11Jus13
 
 
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High impact information on Nxn

  • Redox-dependent activation of the Wnt-beta-catenin pathway occurs independently of extracellular Wnts and is impaired by RNAi of NRX . In addition, association between Dvl and NRX is inhibited by H(2)O(2) treatment [1].
  • It shares the sequence motif Vx3FSAxWCPPCR shown to represent the catalytic site in tryparedoxin I [Gommel et al. (1997) Eur. J. Biochem. 248, 913-918] with mouse nucleoredoxin (accession number X92750), and a thioredoxin-like gene product of Caenorhabditis elegans (accession number U23511) [2].

References

  1. The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled. Funato, Y., Michiue, T., Asashima, M., Miki, H. Nat. Cell Biol. (2006) [Pubmed]
  2. Sequence, heterologous expression and functional characterization of a novel tryparedoxin from Crithidia fasciculata. Montemartini, M., Kalisz, H.M., Kiess, M., Nogoceke, E., Singh, M., Steinert, P., Flohé, L. Biol. Chem. (1998) [Pubmed]
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