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Gene Review

Olfr2  -  olfactory receptor 2

Mus musculus

Synonyms: GA_x6K02T2PBJ9-9381439-9380456, I54, I7, MOR103-15, Olfr41
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High impact information on Olfr2

  • We also found that the mouse I7 receptor, unlike the rat I7 receptor, prefers heptanal instead of octanal, as a result of a single valine-to-isoleucine substitution [1].
  • Similarly the predicted binding sites and affinities for endothelial differential gene 6, mouse and rat I7 olfactory receptors, and human sweet receptor are consistent with the available experimental data [2].
  • In particular we predict that heptanal and octanal both bind strongly to both mouse and rat I7 ORs, which conflicts with the older literature but agrees with recent experiments [3].
  • Axon guidance errors and increased neuronal cell death result in an absence of P2, I7, and M72 glomeruli, indicating a reduction in the repertoire of odorant receptor-specific glomeruli [4].


  1. Identification of ligands for olfactory receptors by functional expression of a receptor library. Krautwurst, D., Yau, K.W., Reed, R.R. Cell (1998) [Pubmed]
  2. Prediction of structure and function of G protein-coupled receptors. Vaidehi, N., Floriano, W.B., Trabanino, R., Hall, S.E., Freddolino, P., Choi, E.J., Zamanakos, G., Goddard, W.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Predicted 3-D structures for mouse I7 and rat I7 olfactory receptors and comparison of predicted odor recognition profiles with experiment. Hall, S.E., Floriano, W.B., Vaidehi, N., Goddard, W.A. Chem. Senses (2004) [Pubmed]
  4. Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons. Henion, T.R., Raitcheva, D., Grosholz, R., Biellmann, F., Skarnes, W.C., Hennet, T., Schwarting, G.A. J. Neurosci. (2005) [Pubmed]
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