Disease relevance of heptanal

• Concentrations of hexanal and heptanal in lung cancer blood were found to be much higher than those in control blood [1].

High impact information on heptanal

• The kinetics of the bacterial luciferase reaction were measured by stopped-flow spectrophotometry at pH 7 and 25 degrees C for the series of aldehydes from n-heptanal to n-undecanal [2].
• Treatment of platelet membranes with trans-2-nonenal and n-heptaldehyde, but not with acetaldehyde, also inhibited membrane-associated PTPase activity [3].
• In the present study, in vivo odorant exposure (heptanal or R-carvone) led to a selective induction of HSP25 in glia-like sustentacular cells in the Swiss Webster mouse OE, as previously shown in rats (Carr et al., 2001) [4].
• On the basis of combined experimental and theoretical evidence, the remaining heptanal photolysis proceeds to form an estimated 10% HCO + hexyl radical and 30% cyclic alcohols, particularly 2-propyl cyclobutanol and 2-ethyl cyclopentanol [5].
• Gas chromatography-mass spectrometric analysis of hexanal and heptanal in human blood by headspace single-drop microextraction with droplet derivatization [6].

Chemical compound and disease context of heptanal

• This further demonstrated that hexanal and heptanal might be the biomarkers of lung cancer [7].

Biological context of heptanal

• Bis(1-hydroxyheptyl)peroxide (BisC7) upon spontaneous hydrolysis affords the difficult-to-isolate ozonation product 1-hydroxy-1-hydroperoxyheptane along with heptanal [8].
• The fluorescence properties, i.e. emission maximum and response of the fluorescence intensity for borohydride reduction, of the products formed by lipid peroxidation of the liposomes were similar to those derived from modification of the liposomes with monofunctional aldehydes such as acetaldehyde and heptaldehyde [9].

Associations of heptanal with other chemical compounds

• In particular we predict that heptanal and octanal both bind strongly to both mouse and rat I7 ORs, which conflicts with the older literature but agrees with recent experiments [10].
• We report the detection of hexanal, heptanal, and nonanal in the bronchoalveolar lavage (BAL) of rats exposed to 0.5 to 10 ppm ozone with or without simultaneous 5% CO2 [11].

References