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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

snf-11  -  Protein SNF-11

Caenorhabditis elegans

 
 
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High impact information on snf-11

  • We show here that snf-11 encodes a functional GABA transporter; SNF-11-mediated GABA transport is Na+ and Cl- dependent, has an EC50 value of 168 microM, and is blocked by the GAT1 inhibitor SKF89976A [1].
 

Associations of snf-11 with chemical compounds

  • Here we report on the cloning and functional characterization of a GABA transporter from C. elegans (ceGAT-1) and on the functional relevance of the transporter to the biology of body muscles and enteric muscles. ceGAT-1 is coded by snf-11 gene, a member of the sodium-dependent neurotransmitter symporter gene family in C. elegans [2].
 

Analytical, diagnostic and therapeutic context of snf-11

References

  1. The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA. Mullen, G.P., Mathews, E.A., Saxena, P., Fields, S.D., McManus, J.R., Moulder, G., Barstead, R.J., Quick, M.W., Rand, J.B. Mol. Biol. Cell (2006) [Pubmed]
  2. A Na+/Cl- -coupled GABA transporter, GAT-1, from Caenorhabditis elegans: structural and functional features, specific expression in GABA-ergic neurons, and involvement in muscle function. Jiang, G., Zhuang, L., Miyauchi, S., Miyake, K., Fei, Y.J., Ganapathy, V. J. Biol. Chem. (2005) [Pubmed]
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