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Chemical Compound Review

CHEMBL38686     1-(4,4-diphenylbut-3- enyl)piperidine-3...

Synonyms: SureCN676998, ACMC-20lzs6, SKF-89976, CHEBI:156963, CCG-205225, ...
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Disease relevance of SKF89976A

  • Toxic doses of SKF89976A caused generalized paroxysmal EEG discharges and myoclonus, but AD generation in the kindled focus was suppressed completely [1].

High impact information on SKF89976A


Biological context of SKF89976A

  • Dose-response curves showed that SKF89976A has an IC50 of 0.93 microM and a Hill coefficient of 2.68 [7].

Associations of SKF89976A with other chemical compounds


  1. Comparative study of the anticonvulsant effect of gamma-aminobutyric acid agonists in the feline kindling model of epilepsy. Morimoto, K., Sanei, T., Sato, K. Epilepsia (1993) [Pubmed]
  2. Passive water and ion transport by cotransporters. Loo, D.D., Hirayama, B.A., Meinild, A.K., Chandy, G., Zeuthen, T., Wright, E.M. J. Physiol. (Lond.) (1999) [Pubmed]
  3. Role of taurine uptake on the induction of long-term synaptic potentiation. del Olmo, N., Suárez, L.M., Orensanz, L.M., Suárez, F., Bustamante, J., Duarte, J.M., Martín del Río, R., Solís, J.M. Eur. J. Neurosci. (2004) [Pubmed]
  4. Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters. Hirayama, B.A., Díez-Sampedro, A., Wright, E.M. Br. J. Pharmacol. (2001) [Pubmed]
  5. Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy. Morimoto, K., Sato, H., Yamamoto, Y., Watanabe, T., Suwaki, H. Epilepsia (1997) [Pubmed]
  6. Modulation of the in vivo effects of gabapentin by vigabatrin and SKF89976A. Stringer, J.L., Aribi, A.M. Epilepsy Res. (2002) [Pubmed]
  7. Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. Takahashi, K., Miyoshi, S., Kaneko, A., Copenhagen, D.R. Jpn. J. Physiol. (1995) [Pubmed]
  8. Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-receptor channels. Quilichini, P.P., Chiron, C., Ben-Ari, Y., Gozlan, H. Epilepsia (2006) [Pubmed]
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