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Gene Review:

Rasgrf1 - RAS protein-specific guanine nucleotide...

Rattus norvegicus

Synonyms: GNRP, Guanine nucleotide-releasing protein, P140 Ras-GRF, Ras-GRF1, Ras-specific guanine nucleotide-releasing factor 1

Pearsall, R.S. et al., Shivakrupa, n.u.l.l. et al., Rozakis-Adcock, M. et al.

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High impact information on Rasgrf1

Grb2 therefore appears to link tyrosine kinases to a Ras-GNRP in mammalian cells [1].
A direct repeat sequence at the Rasgrf1 locus and imprinted expression [2].
This area of chromosome 9 also contains a short, direct tandem repeat in close proximity to a paternally methylated NotI site 30 kb upstream of Rasgrf1 [2].
We have recently identified a portion of mouse chromosome 9 containing a paternally methylated region associated with a paternally expressed imprinted gene, Ras protein-specific guanine nucleotide-releasing factor 1 (Rasgrf1) [2].
C3G is a guanine nucleotide-releasing protein that binds to the Src homology 3 (SH3) domain of the adapter protein Crk [3].

References

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T., Bowtell, D. Nature (1993) [Pubmed]
A direct repeat sequence at the Rasgrf1 locus and imprinted expression. Pearsall, R.S., Plass, C., Romano, M.A., Garrick, M.D., Shibata, H., Hayashizaki, Y., Held, W.A. Genomics (1999) [Pubmed]
Identification of a novel splice variant of C3G which shows tissue-specific expression. Shivakrupa, n.u.l.l., Singh, R., Swarup, G. DNA Cell Biol. (1999) [Pubmed]

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