Gene Review:
RASGRF1 - Ras protein-specific guanine nucleotide...
Homo sapiens
Synonyms:
CDC25, CDC25L, GNRP, GRF1, GRF55, ...
- Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. Hrimech, M., Yao, X.J., Branton, P.E., Cohen, E.A. EMBO J. (2000)
- Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele. Clucas, C., Cabello, J., Büssing, I., Schnabel, R., Johnstone, I.L. EMBO J. (2002)
- MAPK-specific tyrosine phosphatases: new targets for drug discovery? Barr, A.J., Knapp, S. Trends Pharmacol. Sci. (2006)
- cdc25 cell cycle-activating phosphatases and c-myc expression in human non-Hodgkin's lymphomas. Hernández, S., Hernández, L., Beà, S., Cazorla, M., Fernández, P.L., Nadal, A., Muntané, J., Mallofré, C., Montserrat, E., Cardesa, A., Campo, E. Cancer Res. (1998)
- Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone. Brisson, M., Foster, C., Wipf, P., Joo, B., Tomko, R.J., Nguyen, T., Lazo, J.S. Mol. Pharmacol. (2007)
- Inhibitors of the CDC25 phosphatases. Prevost, G.P., Brezak, M.C., Goubin, F., Mondesert, O., Galcera, M.O., Quaranta, M., Alby, F., Lavergne, O., Ducommun, B. Progress in cell cycle research. (2003)
- PTEN and myotubularin: novel phosphoinositide phosphatases. Maehama, T., Taylor, G.S., Dixon, J.E. Annu. Rev. Biochem. (2001)
- Regulation of Cdc25C by ERK-MAP Kinases during the G(2)/M Transition. Wang, R., He, G., Nelman-Gonzalez, M., Ashorn, C.L., Gallick, G.E., Stukenberg, P.T., Kirschner, M.W., Kuang, J. Cell (2007)
- Role for the PP2A/B56delta Phosphatase in Regulating 14-3-3 Release from Cdc25 to Control Mitosis. Margolis, S.S., Perry, J.A., Forester, C.M., Nutt, L.K., Guo, Y., Jardim, M.J., Thomenius, M.J., Freel, C.D., Darbandi, R., Ahn, J.H., Arroyo, J.D., Wang, X.F., Shenolikar, S., Nairn, A.C., Dunphy, W.G., Hahn, W.C., Virshup, D.M., Kornbluth, S. Cell (2006)
- H32, a Non-Quinone Sulfone Analog of Vitamin K3, Inhibits Human Hepatoma Cell Growth by Inhibiting Cdc25 and Activating ERK. Kar, S., Wang, M., Ham, S.W., Carr, B.I. Cancer Biol. Ther. (2006)
- Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2. de Hoog, C.L., Koehler, J.A., Goldstein, M.D., Taylor, P., Figeys, D., Moran, M.F. Mol. Cell. Biol. (2001)
- Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src. Kiyono, M., Kaziro, Y., Satoh, T. J. Biol. Chem. (2000)
- The cdc25 M-phase inducer: an unconventional protein phosphatase. Millar, J.B., Russell, P. Cell (1992)
- Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Fauman, E.B., Cogswell, J.P., Lovejoy, B., Rocque, W.J., Holmes, W., Montana, V.G., Piwnica-Worms, H., Rink, M.J., Saper, M.A. Cell (1998)
- Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Furnari, B., Rhind, N., Russell, P. Science (1997)
- Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. Kiyono, M., Kato, J., Kataoka, T., Kaziro, Y., Satoh, T. J. Biol. Chem. (2000)
- Mitotic phosphatases: no longer silent partners. Trinkle-Mulcahy, L., Lamond, A.I. Curr. Opin. Cell Biol. (2006)
- Dual mode of degradation of Cdc25 A phosphatase. Donzelli, M., Squatrito, M., Ganoth, D., Hershko, A., Pagano, M., Draetta, G.F. EMBO J. (2002)
- Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Sadhu, K., Reed, S.I., Richardson, H., Russell, P. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Calmodulin-independent coordination of Ras and extracellular signal-regulated kinase activation by Ras-GRF2. de Hoog, C.L., Fan, W.T., Goldstein, M.D., Moran, M.F., Koch, C.A. Mol. Cell. Biol. (2000)
- A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea. Nishijima, H., Nishitani, H., Seki, T., Nishimoto, T. J. Cell Biol. (1997)
- The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Shen, M., Stukenberg, P.T., Kirschner, M.W., Lu, K.P. Genes Dev. (1998)
- Study of the cytolethal distending toxin-induced cell cycle arrest in HeLa cells: involvement of the CDC25 phosphatase. Escalas, N., Davezac, N., De Rycke, J., Baldin, V., Mazars, R., Ducommun, B. Exp. Cell Res. (2000)
- Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI). Kyono, W.T., de Jong, R., Park, R.K., Liu, Y., Heisterkamp, N., Groffen, J., Durden, D.L. J. Immunol. (1998)
- HABP1/p32/gC1qR induces aberrant growth and morphology in Schizosaccharomyces pombe through its N-terminal alpha helix. Mallick, J., Datta, K. Exp. Cell Res. (2005)
- HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. Elder, R.T., Yu, M., Chen, M., Zhu, X., Yanagida, M., Zhao, Y. Virology (2001)
- Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer. Ozen, M., Ittmann, M. Clin. Cancer Res. (2005)
- Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex. Gabrielli, B.G., Lee, M.S., Walker, D.H., Piwnica-Worms, H., Maller, J.L. J. Biol. Chem. (1992)
- Use of CDC2 from etoposide-treated cells as substrate to assay CDC25 phosphatase activity. Cans, C., Sert, V., De Rycke, J., Baldin, V., Ducommun, B. Anticancer Res. (1999)
- Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi. Loukaci, A., Le Saout, I., Samadi, M., Leclerc, S., Damiens, E., Meijer, L., Debitus, C., Guyot, M. Bioorg. Med. Chem. (2001)
- Cdc2 regulatory factors. Coleman, T.R., Dunphy, W.G. Curr. Opin. Cell Biol. (1994)
- Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. Gu, Y., Rosenblatt, J., Morgan, D.O. EMBO J. (1992)
- Overexpression of cyclin-dependent kinase-activating CDC25B phosphatase in human gastric carcinomas. Kudo, Y., Yasui, W., Ue, T., Yamamoto, S., Yokozaki, H., Nikai, H., Tahara, E. Jpn. J. Cancer Res. (1997)
- A fission yeast strain expressing human CDC25A phosphatase: a tool for selectivity studies of pharmacological inhibitors of CDC25. Mondesert, O., Lemaire, M., Brezak, M.C., Galera-Contour, M.O., Prevost, G., Ducommun, B., Bugler, B. Curr. Genet. (2004)
- G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm). Kiyono, M., Satoh, T., Kaziro, Y. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. Strausfeld, U., Fernandez, A., Capony, J.P., Girard, F., Lautredou, N., Derancourt, J., Labbe, J.C., Lamb, N.J. J. Biol. Chem. (1994)
- Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization. Takai, S., Tanaka, M., Sugimura, H., Yamada, K., Naito, Y., Kino, I., Matsuda, M. Hum. Genet. (1994)
- Modulation of bcl-2 family proteins in MAPK independent apoptosis induced by a cdc25 phosphatase inhibitor Cpd 5 in renal cancer cells. Mizuno, R., Oya, M., Hara, S., Matsumoto, M., Horiguchi, A., Ohigashi, T., Marumo, K., Murai, M. Oncol. Rep. (2005)
- Higher eucaryotic cdc25 proteins are structurally related to phosphoseryl/threonyl protein phosphatases. Bellé, R., Ollivier, E., Guerrucci, M.A. Biol. Cell (1992)
- Failure to inactivate CDK activity is responsible for the enhanced apoptotic response in U937 cells mediated by silencing ATM gene. Deng, J., Zhou, J., Meng, F., Li, D., Sun, H. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2002)