The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Autoimmunity

  • Consequently, the role of IFN-alpha/beta in the pathogenesis of autoimmunity remains at the forefront of scientific inquiry and has begun to illuminate the mechanisms by which these molecules promote or inhibit systemic and organ-specific autoimmune diseases [1].
  • To identify environmental agents that could potentially incite autoimmunity, we have traced the autoantibody response in human SLE back in time, prior to clinical disease onset, and identified the initial autoantigenic epitope for some lupus patients positive for antibodies to 60 kDa Ro [2].
  • Heterozygous mutations in CD95, CD95 ligand or caspase-10 underlie most cases of autoimmune lymphoproliferative syndrome (ALPS), a human disorder that is characterized by defective lymphocyte apoptosis, lymphadenopathy, splenomegaly and autoimmunity [3].
  • There is some circumstantial evidence for an autoimmune pathogenesis in idiopathic POF patients in the absence of adrenal autoimmunity or Addison's disease [4].
  • These cells, strategically located in the thymus, may play a role in initiation of the autoimmune response against acetylcholine receptors, which is characteristic of myasthenia gravis [5].

Psychiatry related information on Autoimmunity


High impact information on Autoimmunity

  • Pharmacological disruption of this network in human autoimmune diseases such as rheumatoid arthritis alleviates inflammation in a significant number of patients, but not in other diseases, a finding that challenges our molecular paradigms of autoimmunity and perhaps will reveal novel roles for this network in pathogenesis [10].
  • This review describes the function of CD1-restricted T cells in antimicrobial responses, antitumor immunity, and in regulating the balance between tolerance and autoimmunity [11].
  • Deficiency or mutation of some of the E3s like Cbl, Cbl-b, or Itch, causes abnormal immune responses such as autoimmunity, malignancy, and inflammation [12].
  • BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients [13].
  • Based on the PLP 139-151 system, we propose a model in which activation with foreign antigens can result in the generation of pathogenic memory T cells that mediate autoimmunity [14].

Chemical compound and disease context of Autoimmunity


Biological context of Autoimmunity


Anatomical context of Autoimmunity


Associations of Autoimmunity with chemical compounds


Gene context of Autoimmunity


Analytical, diagnostic and therapeutic context of Autoimmunity


  1. Type I interferons (alpha/beta) in immunity and autoimmunity. Theofilopoulos, A.N., Baccala, R., Beutler, B., Kono, D.H. Annu. Rev. Immunol. (2005) [Pubmed]
  2. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. McClain, M.T., Heinlen, L.D., Dennis, G.J., Roebuck, J., Harley, J.B., James, J.A. Nat. Med. (2005) [Pubmed]
  3. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Chun, H.J., Zheng, L., Ahmad, M., Wang, J., Speirs, C.K., Siegel, R.M., Dale, J.K., Puck, J., Davis, J., Hall, C.G., Skoda-Smith, S., Atkinson, T.P., Straus, S.E., Lenardo, M.J. Nature (2002) [Pubmed]
  4. Premature ovarian failure and ovarian autoimmunity. Hoek, A., Schoemaker, J., Drexhage, H.A. Endocr. Rev. (1997) [Pubmed]
  5. Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis. Kao, I., Drachman, D.B. Science (1977) [Pubmed]
  6. A high prevalence of organ-specific autoimmunity in patients with bipolar disorder. Padmos, R.C., Bekris, L., Knijff, E.M., Tiemeier, H., Kupka, R.W., Cohen, D., Nolen, W.A., Lernmark, A., Drexhage, H.A. Biol. Psychiatry (2004) [Pubmed]
  7. The influence of aging on the induction and manifestations of experimental systemic lupus erythematosus. Segal, R., Globerson, A., Zinger, H., Mozes, E. J. Clin. Immunol. (1992) [Pubmed]
  8. Immunoblot detection of antibodies to myelin basic protein in Alzheimer's disease patients. Singh, V.K., Yang, Y.Y., Singh, E.A. Neurosci. Lett. (1992) [Pubmed]
  9. Association between panic disorder, major depressive disorder and celiac disease: a possible role of thyroid autoimmunity. Carta, M.G., Hardoy, M.C., Boi, M.F., Mariotti, S., Carpiniello, B., Usai, P. Journal of psychosomatic research. (2002) [Pubmed]
  10. Network communications: lymphotoxins, LIGHT, and TNF. Ware, C.F. Annu. Rev. Immunol. (2005) [Pubmed]
  11. CD1: antigen presentation and T cell function. Brigl, M., Brenner, M.B. Annu. Rev. Immunol. (2004) [Pubmed]
  12. Ubiquitin ligases and the immune response. Liu, Y.C. Annu. Rev. Immunol. (2004) [Pubmed]
  13. BAFF AND APRIL: a tutorial on B cell survival. Mackay, F., Schneider, P., Rennert, P., Browning, J. Annu. Rev. Immunol. (2003) [Pubmed]
  14. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Kuchroo, V.K., Anderson, A.C., Waldner, H., Munder, M., Bettelli, E., Nicholson, L.B. Annu. Rev. Immunol. (2002) [Pubmed]
  15. Protective autoimmunity against the enemy within: fighting glutamate toxicity. Schwartz, M., Shaked, I., Fisher, J., Mizrahi, T., Schori, H. Trends Neurosci. (2003) [Pubmed]
  16. Aberrant production of leukotriene C4 by macrophages from autoimmune-prone mice. Santoro, T.J., Morris, D.H., Murphy, R.C., Baker, R.C. J. Exp. Med. (1988) [Pubmed]
  17. Autoimmunity to gephyrin in Stiff-Man syndrome. Butler, M.H., Hayashi, A., Ohkoshi, N., Villmann, C., Becker, C.M., Feng, G., De Camilli, P., Solimena, M. Neuron (2000) [Pubmed]
  18. Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Hiemstra, H.S., Schloot, N.C., van Veelen, P.A., Willemen, S.J., Franken, K.L., van Rood, J.J., de Vries, R.R., Chaudhuri, A., Behan, P.O., Drijfhout, J.W., Roep, B.O. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  19. Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross-reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex. Surh, C.D., Roche, T.E., Danner, D.J., Ansari, A., Coppel, R.L., Prindiville, T., Dickson, E.R., Gershwin, M.E. Hepatology (1989) [Pubmed]
  20. MHC class-II molecules and autoimmunity. Nepom, G.T., Erlich, H. Annu. Rev. Immunol. (1991) [Pubmed]
  21. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Tedder, T.F., Tuscano, J., Sato, S., Kehrl, J.H. Annu. Rev. Immunol. (1997) [Pubmed]
  22. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Wucherpfennig, K.W., Strominger, J.L. Cell (1995) [Pubmed]
  23. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Salzer, U., Chapel, H.M., Webster, A.D., Pan-Hammarström, Q., Schmitt-Graeff, A., Schlesier, M., Peter, H.H., Rockstroh, J.K., Schneider, P., Schäffer, A.A., Hammarström, L., Grimbacher, B. Nat. Genet. (2005) [Pubmed]
  24. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Majeti, R., Xu, Z., Parslow, T.G., Olson, J.L., Daikh, D.I., Killeen, N., Weiss, A. Cell (2000) [Pubmed]
  25. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Bachmaier, K., Krawczyk, C., Kozieradzki, I., Kong, Y.Y., Sasaki, T., Oliveira-dos-Santos, A., Mariathasan, S., Bouchard, D., Wakeham, A., Itie, A., Le, J., Ohashi, P.S., Sarosi, I., Nishina, H., Lipkowitz, S., Penninger, J.M. Nature (2000) [Pubmed]
  26. TH1 and TH2 cytokine control of thyrocyte survival in thyroid autoimmunity. Mirakian, R., Hammond, L.J., Bottazzo, G.F. Nat. Immunol. (2001) [Pubmed]
  27. CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'. Perchellet, A., Stromnes, I., Pang, J.M., Goverman, J. Nat. Immunol. (2004) [Pubmed]
  28. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. Horai, R., Saijo, S., Tanioka, H., Nakae, S., Sudo, K., Okahara, A., Ikuse, T., Asano, M., Iwakura, Y. J. Exp. Med. (2000) [Pubmed]
  29. Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model. Larger, E., Bécourt, C., Bach, J.F., Boitard, C. J. Exp. Med. (1995) [Pubmed]
  30. Leukocyte protein tyrosine kinases: potential targets for drug discovery. Bolen, J.B., Brugge, J.S. Annu. Rev. Immunol. (1997) [Pubmed]
  31. A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group. Imagawa, A., Hanafusa, T., Miyagawa, J., Matsuzawa, Y. N. Engl. J. Med. (2000) [Pubmed]
  32. Strain differences in the autoimmune response of mice to acetylcholine receptors. Fuchs, S., Nevo, D., Tarrab-Hazdai, R., Yaar, I. Nature (1976) [Pubmed]
  33. Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice. Lamhamedi-Cherradi, S.E., Zheng, S.J., Maguschak, K.A., Peschon, J., Chen, Y.H. Nat. Immunol. (2003) [Pubmed]
  34. Mercury-induced autoreactive anti-class II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats. Castedo, M., Pelletier, L., Rossert, J., Pasquier, R., Villarroya, H., Druet, P. J. Exp. Med. (1993) [Pubmed]
  35. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Kochi, Y., Yamada, R., Suzuki, A., Harley, J.B., Shirasawa, S., Sawada, T., Bae, S.C., Tokuhiro, S., Chang, X., Sekine, A., Takahashi, A., Tsunoda, T., Ohnishi, Y., Kaufman, K.M., Kang, C.P., Kang, C., Otsubo, S., Yumura, W., Mimori, A., Koike, T., Nakamura, Y., Sasazuki, T., Yamamoto, K. Nat. Genet. (2005) [Pubmed]
  36. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Yokoi, N., Komeda, K., Wang, H.Y., Yano, H., Kitada, K., Saitoh, Y., Seino, Y., Yasuda, K., Serikawa, T., Seino, S. Nat. Genet. (2002) [Pubmed]
  37. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Grewal, I.S., Foellmer, H.G., Grewal, K.D., Xu, J., Hardardottir, F., Baron, J.L., Janeway, C.A., Flavell, R.A. Science (1996) [Pubmed]
  38. Impaired Fas response and autoimmunity in Pten+/- mice. Di Cristofano, A., Kotsi, P., Peng, Y.F., Cordon-Cardo, C., Elkon, K.B., Pandolfi, P.P. Science (1999) [Pubmed]
  39. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Seshasayee, D., Valdez, P., Yan, M., Dixit, V.M., Tumas, D., Grewal, I.S. Immunity (2003) [Pubmed]
  40. Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen. Burlingame, R.W., Rubin, R.L., Balderas, R.S., Theofilopoulos, A.N. J. Clin. Invest. (1993) [Pubmed]
  41. Metabolism of procainamide to the cytotoxic hydroxylamine by neutrophils activated in vitro. Rubin, R.L., Curnutte, J.T. J. Clin. Invest. (1989) [Pubmed]
  42. Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis. Angelov, D.N., Waibel, S., Guntinas-Lichius, O., Lenzen, M., Neiss, W.F., Tomov, T.L., Yoles, E., Kipnis, J., Schori, H., Reuter, A., Ludolph, A., Schwartz, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  43. Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide). Karussis, D.M., Lehmann, D., Slavin, S., Vourka-Karussis, U., Mizrachi-Koll, R., Ovadia, H., Kalland, T., Abramsky, O. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  44. Adoptive transfer of skin-selective autoimmunity induced by Skn alloantigenic disparities. Jackman, S.H., Boyse, E.A., Goldberg, E.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
WikiGenes - Universities