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Gene Review:

Rb(6.16)24Lub - Robertsonian translocation, Chr 6 and 16,...

Mus musculus

Synonyms: Rb(6.16)24Lubx, Rb24Lub

Di Stefano, T.V. et al., Di Stefano, T.V. et al., Deng, X. et al., Villar, A.J. et al., Zackowski, J.L. et al.

Villar, Kim, De Blank, Gillespie, Kozy, Ursell, Epstein,

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High impact information on Rb(6.16)24Lub

To investigate the genetic contribution to phenotypic variability in aneuploidy, we generated mice with trisomy 16 (Ts16) by mating [Rb(6.16)24Lub x Rb(16.17)7Bnr]F1 males with females from four inbred strains, BALB/cJ, C3H/HeJ, C57BL/6J, and DBA/2J [1].
It thus places the gene near the centromere and the junction of the Rb(6.16)24Lub and Rb(6.15)1Ald translocations [2].
Males and females homozygous for the Robertsonian translocation specific for chromosomes 16 and 17 Rb(16.17)Bnr and male and females homozygous for the Robertsonian translocation for chromosomes 6 and 16 Rb(6.16)24Lub were bred to produce double heterozygotes [Rb(16.17)Bnr/Rb(6.16)24Lub] [3].
Stocks used were male and female monozygotes for Robertsonian translocation specific for chromosomes 16 and 17 Rb(16.17)7Bnr and males and females homozygous for Robertsonian translocation for chromosomes 6 and 16 Rb(6.16)24Lub to produce double heterozygotes characterized as Rb(16.17)Bnr/Rb(6.16)24Lub [4].

Biological context of Rb(6.16)24Lub

The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes [2].
The meiotic segregants of male mice heterozygous for Rb(6.16)24Lub and Rb(16.17)7Bnr were viewed, for the first time, at first cleavage metaphase [5].

References

Effects of genetic background on cardiovascular anomalies in the Ts16 mouse. Villar, A.J., Kim, J., De Blank, P., Gillespie, A.M., Kozy, H.M., Ursell, P.C., Epstein, C.J. Dev. Dyn. (2005) [Pubmed]
The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes. Deng, X., Moran, J., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Primakoff, P., Martin-DeLeon, P.A. Mamm. Genome (1997) [Pubmed]
Osteogenesis of the mandibular arch in Ts16 mice. Di Stefano, T.V., Provenza, D.V. Arch. Oral Biol. (1994) [Pubmed]
Molar odontogenesis in the trisomic 16 mouse. Di Stefano, T.V., Provenza, D.V. Arch. Oral Biol. (1993) [Pubmed]
Segregation products of male mice doubly heterozygous for the RB(6.16) and RB (16.17) translocations: influence of sperm karyotype on fertilizing competence under varying mating frequencies. Zackowski, J.L., Martin-DeLeon, P.A. Gamete research. (1989) [Pubmed]

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