The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Metaphase


High impact information on Metaphase


Chemical compound and disease context of Metaphase


Biological context of Metaphase


Anatomical context of Metaphase

  • Neuroblasts in Drosophila larvae homozygous for a null mutation in the awd gene are arrested in metaphase, indicating that microtubule-associated Awd/NDP kinase plays a critical role in spindle microtubule polymerization [21].
  • Normal primary cells and tumour cell lines that express wild-type chfr exhibited delayed entry into metaphase when centrosome separation was inhibited by mitotic stress [22].
  • In vertebrates, unfertilized eggs are arrested at second meiotic metaphase by a cytostatic factor (CSF), an essential component of which is the product of the c-mos proto-oncogene [23].
  • Lymphocytes from respective patients were cultured, exposed to the clastogen bleomycin, arrested during metaphase, and examined quantitatively for chromosome breakage [24].
  • A later requirement for actin metaphase furrows in preventing the nucleation of mitotic spindles between inappropriate centrosomes is observed [25].

Associations of Metaphase with chemical compounds


Gene context of Metaphase


Analytical, diagnostic and therapeutic context of Metaphase


  1. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. DiPaolo, J.A., Amsbaugh, S.C., Popescu, N.C. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  2. Assignment of CSF-1 to 5q33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Pettenati, M.J., Le Beau, M.M., Lemons, R.S., Shima, E.A., Kawasaki, E.S., Larson, R.A., Sherr, C.J., Diaz, M.O., Rowley, J.D. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  3. Molecular heterogeneity in complete cytogenetic responders after interferon-alpha therapy for chronic myelogenous leukemia: low levels of minimal residual disease are associated with continuing remission. German CML Study Group and the UK MRC CML Study Group. Hochhaus, A., Reiter, A., Saussele, S., Reichert, A., Emig, M., Kaeda, J., Schultheis, B., Berger, U., Shepherd, P.C., Allan, N.C., Hehlmann, R., Goldman, J.M., Cross, N.C. Blood (2000) [Pubmed]
  4. Characterization and chromosomal localization of the human proto-oncogene BMI-1. Alkema, M.J., Wiegant, J., Raap, A.K., Berns, A., van Lohuizen, M. Hum. Mol. Genet. (1993) [Pubmed]
  5. Mouse molecular cytogenetic resource: 157 BACs link the chromosomal and genetic maps. Korenberg, J.R., Chen, X.N., Devon, K.L., Noya, D., Oster-Granite, M.L., Birren, B.W. Genome Res. (1999) [Pubmed]
  6. Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Du, Q., Macara, I.G. Cell (2004) [Pubmed]
  7. Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Gilbert, N., Boyle, S., Fiegler, H., Woodfine, K., Carter, N.P., Bickmore, W.A. Cell (2004) [Pubmed]
  8. Meiotic arrest and aneuploidy in MLH3-deficient mice. Lipkin, S.M., Moens, P.B., Wang, V., Lenzi, M., Shanmugarajah, D., Gilgeous, A., Thomas, J., Cheng, J., Touchman, J.W., Green, E.D., Schwartzberg, P., Collins, F.S., Cohen, P.E. Nat. Genet. (2002) [Pubmed]
  9. Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation. Gibbons, R.J., McDowell, T.L., Raman, S., O'Rourke, D.M., Garrick, D., Ayyub, H., Higgs, D.R. Nat. Genet. (2000) [Pubmed]
  10. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Uhlmann, F., Wernic, D., Poupart, M.A., Koonin, E.V., Nasmyth, K. Cell (2000) [Pubmed]
  11. Chromosome analysis and alkaline phosphatase of C41, a cell line of human cervical origin distinct from HeLa. Herz, F., Miller, O.J., Miller, D.A., Auersperg, N., Koss, L.G. Cancer Res. (1977) [Pubmed]
  12. Effects of hydroxyurea on extrachromosomal DNA in patients with advanced ovarian carcinomas. Raymond, E., Faivre, S., Weiss, G., McGill, J., Davidson, K., Izbicka, E., Kuhn, J.G., Allred, C., Clark, G.M., Von Hoff, D.D. Clin. Cancer Res. (2001) [Pubmed]
  13. Cell kinetics of urethane-induced murine pulmonary adenomas: III. Implications of the disparity between the rates of entry into DNA synthesis and into mitosis. Dyson, P., Heppleston, A.G. Br. J. Cancer (1977) [Pubmed]
  14. The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5. Weremowicz, S., Fox, E.A., Morton, C.C., Vallee, B.L. Genomics (1990) [Pubmed]
  15. Synchronization of cell division in eight-cell bovine embryos produced in vitro: effects of nocodazole. Samaké, S., Smith, L.C. Mol. Reprod. Dev. (1996) [Pubmed]
  16. The Drosophila maternal-effect gene fs(1)Ya encodes a cell cycle-dependent nuclear envelope component required for embryonic mitosis. Lin, H.F., Wolfner, M.F. Cell (1991) [Pubmed]
  17. Microinjection of the nonhistone chromosomal protein HMG1 into bovine fibroblasts and HeLa cells. Rechsteiner, M., Kuehl, L. Cell (1979) [Pubmed]
  18. Parthenogenetic activation of oocytes in c-mos-deficient mice. Hashimoto, N., Watanabe, N., Furuta, Y., Tamemoto, H., Sagata, N., Yokoyama, M., Okazaki, K., Nagayoshi, M., Takeda, N., Ikawa, Y. Nature (1994) [Pubmed]
  19. S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Ghislain, M., Udvardy, A., Mann, C. Nature (1993) [Pubmed]
  20. Calpain II involvement in mitosis. Schollmeyer, J.E. Science (1988) [Pubmed]
  21. A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Biggs, J., Hersperger, E., Steeg, P.S., Liotta, L.A., Shearn, A. Cell (1990) [Pubmed]
  22. Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Scolnick, D.M., Halazonetis, T.D. Nature (2000) [Pubmed]
  23. Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs. Lorca, T., Cruzalegui, F.H., Fesquet, D., Cavadore, J.C., Méry, J., Means, A., Dorée, M. Nature (1993) [Pubmed]
  24. Young adults with head and neck cancer express increased susceptibility to mutagen-induced chromosome damage. Schantz, S.P., Hsu, T.C., Ainslie, N., Moser, R.P. JAMA (1989) [Pubmed]
  25. Maternal effect mutations of the sponge locus affect actin cytoskeletal rearrangements in Drosophila melanogaster embryos. Postner, M.A., Miller, K.G., Wieschaus, E.F. J. Cell Biol. (1992) [Pubmed]
  26. Localization of 5-methylcytosine in human metaphase chromosomes by immunoelectron microscopy. Lubit, B.W., Pham, T.D., Miller, O.J., Erlanger, B.F. Cell (1976) [Pubmed]
  27. Reverse banding on chromosomes produced by a guanosine-cytosine specific DNA binding antibiotic: olivomycin. van de Sande, J.H., Lin, C.C., Jorgenson, K.F. Science (1977) [Pubmed]
  28. Chromosome methylation patterns during mammalian preimplantation development. Rougier, N., Bourc'his, D., Gomes, D.M., Niveleau, A., Plachot, M., Pàldi, A., Viegas-Péquignot, E. Genes Dev. (1998) [Pubmed]
  29. Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes. Perez, L.H., Antonio, C., Flament, S., Vernos, I., Nebreda, A.R. Nat. Cell Biol. (2002) [Pubmed]
  30. Human fibroblast chromatin states as effectors of the DNA-binding characteristics of benzo[a]pyrene anti-7,8-dihydrodiol 9,10-epoxide and two nonalkylating DNA-binding molecules. Warner, M.R., Iannaccone, P., Fahl, W.E. J. Natl. Cancer Inst. (1986) [Pubmed]
  31. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Yu, H., Peters, J.M., King, R.W., Page, A.M., Hieter, P., Kirschner, M.W. Science (1998) [Pubmed]
  32. Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Kaiser, P., Moncollin, V., Clarke, D.J., Watson, M.H., Bertolaet, B.L., Reed, S.I., Bailly, E. Genes Dev. (1999) [Pubmed]
  33. Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. de Vries, F.A., de Boer, E., van den Bosch, M., Baarends, W.M., Ooms, M., Yuan, L., Liu, J.G., van Zeeland, A.A., Heyting, C., Pastink, A. Genes Dev. (2005) [Pubmed]
  34. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage. Tinker-Kulberg, R.L., Morgan, D.O. Genes Dev. (1999) [Pubmed]
  35. Spo13 regulates cohesin cleavage. Lee, B.H., Amon, A., Prinz, S. Genes Dev. (2002) [Pubmed]
  36. Expression of a histone H1-like protein is restricted to early Xenopus development. Smith, R.C., Dworkin-Rastl, E., Dworkin, M.B. Genes Dev. (1988) [Pubmed]
  37. The scattered distribution of actin genes in the mouse and human genomes. Soriano, P., Szabo, P., Bernardi, G. EMBO J. (1982) [Pubmed]
  38. Localization of caldesmon and its dephosphorylation during cell division. Hosoya, N., Hosoya, H., Yamashiro, S., Mohri, H., Matsumura, F. J. Cell Biol. (1993) [Pubmed]
  39. Tubulin interaction with kinetochore proteins: analysis by in vitro assembly and chemical cross-linking. Balczon, R.D., Brinkley, B.R. J. Cell Biol. (1987) [Pubmed]
WikiGenes - Universities