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Gene Review:

Rb(6.15)1Ald - Robertsonian translocation, Chr 6 and 15,...

Mus musculus

Synonyms: Rb1Ald

Deng, X. et al., Mittwoch, U. et al., Herbst, E.W. et al.

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High impact information on Rb(6.15)1Ald

Thus, the triplication of a whole Rb(6.15) is frequent in leukemic AKR/Rb(6.15)1Ald, and ensuing double trisomy 6 + 15 is tolerated by the leukemic cell [1].
The essential role of the Spam1 sperm antigen in mouse sperm-egg interactions and its gene location provide strong support for its candidacy as the gene involved in the dysfunction of mouse sperm bearing the Rb(6.16)24Lub or Rb(6.15)1Ald translocation [2].
It thus places the gene near the centromere and the junction of the Rb(6.16)24Lub and Rb(6.15)1Ald translocations [2].
Oocyte numbers and synaptonemal complexes were studied in two Robertsonian translocations, Rb(6.15)1Ald and Rb(4.6)2Bnr, and their male-sterile compound [3].

Biological context of Rb(6.15)1Ald

The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes [2].

References

Chromosome rearrangements involved in the origin of trisomy 15 in spontaneous leukemia of AKR mice. Herbst, E.W., Gropp, A., Tietgen, C. Int. J. Cancer (1981) [Pubmed]
The mouse Spam1 maps to proximal chromosome 6 and is a candidate for the sperm dysfunction in Rb(6.16)24Lub and Rb(6.15)1Ald heterozygotes. Deng, X., Moran, J., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Primakoff, P., Martin-DeLeon, P.A. Mamm. Genome (1997) [Pubmed]
Pachytene pairing and oocyte numbers in mice with two single Robertsonian translocations and the male-sterile compound with monobrachial homology. Mittwoch, U., Mahadevaiah, S.K., Setterfield, L.A. Cytogenet. Cell Genet. (1990) [Pubmed]

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