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Gene Review:

Rnu7 - U7 small nuclear RNA

Mus musculus

Quenneville, S.P. et al., Mowry, K.L. et al., Phillips, S.C. et al., Gruber, A. et al., Kirby, B.J. et al.

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Disease relevance of Rnu7

Therapeutic exon skipping was induced by infecting myoblasts of a DMD patient, deleted for dystrophin exons 49 and 50, with a lentivirus expressing a U7 small nuclear RNA containing antisense sequences against exon 51 [1].

High impact information on Rnu7

We found that deletion of the downstream purine-rich element hypothesized to interact with U7 small nuclear RNA abolishes in vitro 3'-end processing [2].
Primer extension analysis of mouse U7 small nuclear RNA gene expression [3].
The mouse U7 small nuclear RNA gene promoter functions efficiently in Xenopus oocytes [4].
Isolation of an active gene and of two pseudogenes for mouse U7 small nuclear RNA [5].

References

Autologous transplantation of muscle precursor cells modified with a lentivirus for muscular dystrophy: human cells and primate models. Quenneville, S.P., Chapdelaine, P., Skuk, D., Paradis, M., Goulet, M., Rousseau, J., Xiao, X., Garcia, L., Tremblay, J.P. Mol. Ther. (2007) [Pubmed]
Each of the conserved sequence elements flanking the cleavage site of mammalian histone pre-mRNAs has a distinct role in the 3'-end processing reaction. Mowry, K.L., Oh, R., Steitz, J.A. Mol. Cell. Biol. (1989) [Pubmed]
Primer extension analysis of mouse U7 small nuclear RNA gene expression. Kirby, B.J., Turner, P.C. Biochem. Soc. Trans. (1992) [Pubmed]
The mouse U7 small nuclear RNA gene promoter functions efficiently in Xenopus oocytes. Phillips, S.C., Turner, P.C. Biochem. Soc. Trans. (1991) [Pubmed]
Isolation of an active gene and of two pseudogenes for mouse U7 small nuclear RNA. Gruber, A., Soldati, D., Burri, M., Schümperli, D. Biochim. Biophys. Acta (1991) [Pubmed]

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