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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CREG2  -  cellular repressor of E1A-stimulated genes 2

Homo sapiens

Synonyms: Protein CREG2
 
 
 
 
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High impact information on CREG2

  • Northern blot analyses demonstrate specific CREG2 and Creg2 transcription in brain-in the case of CREG2, mainly in the limbic system of the brain [1].
  • Human and mouse CREG2 are N-glycosylated in HeLa cells and deletion of amino-terminal sequences completely abolishes N-glycosylation, indicating that the N termini of both proteins may function as signal sequences [1].
  • Both mouse and human CREG2 fused to the carboxy terminus of EGFP in NIH3T3 cells localize to the perinuclear region, which demonstrates implicit endoplasmic reticulum and Golgi localization [1].

References

  1. Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain. Kunita, R., Otomo, A., Ikeda, J.E. Genomics (2002) [Pubmed]
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