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Gene Review

STT3B  -  STT3B, subunit of the oligosaccharyltransf...

Homo sapiens

Synonyms: CDG1X, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B, FLJ90106, Oligosaccharyl transferase subunit STT3B, SIMP, ...


This protein is a subunit of the OST complex, which attaches a 14-sugars N-glycan precursor to proteins being translated in the ER,to a Asn-X-Thr/Ser sequon.


High impact information on STT3B

  • Relevant key features of SIMP/STT3B are its lysine-rich region, its propensity to misfold and its location in the ER membrane in close proximity to the immunoproteasome [1].
  • We show that the endoplasmic reticulum (ER)-associated degradation pathway and MHC I processing intersect at SIMP/STT3B [1].
  • We also identified a bipartite nuclear targeting sequence in the C-terminal tail of STT3-B that is absent in STT3-A [2].
  • Strikingly, while the difference in the amino acid sequence 770-778 encoded by the two SIMP alleles represents a very conservative substitution, these allelic peptides were not crossreactive at the CTL level, and both peptides were immunodominant when presented to mice homozygous for the opposite allele [3].
  • Phenotypic and genotypic analyses among eight strains of mice revealed a precise correlation between susceptibility or resistance to B6(dom1)-specific cytotoxic T lymphocytes (CTLs) and the presence of a Glu vs Asp amino acid at position 776 of the SIMP protein, respectively [3].

Analytical, diagnostic and therapeutic context of STT3B

  • When topical therapy with a 1 mmol/l solution of SIMP was initiated after corneal ulceration had progressed to a mid-stromal level (clinical score of 2), there was no significant difference in the progression of corneal ulceration between the treated vs. control group after 6 d of therapy [4].
  • We demonstrated that there was good agreement between LVEF determined using both MANUAL SIMP and semiautomated endocardial border detection, and radionuclide angiography (standard of comparison) [5].


  1. The structure and location of SIMP/STT3B account for its prominent imprint on the MHC I immunopeptidome. Caron, E., Charbonneau, R., Huppé, G., Brochu, S., Perreault, C. Int. Immunol. (2005) [Pubmed]
  2. Identification of two distinct intracellular localization signals in STT3-B. Caron, E., Côté, C., Parisien, M., Major, F., Perreault, C. Arch. Biochem. Biophys. (2006) [Pubmed]
  3. The model B6(dom1) minor histocompatibility antigen is encoded by a mouse homolog of the yeast STT3 gene. McBride, K., Baron, C., Picard, S., Martin, S., Boismenu, D., Bell, A., Bergeron, J., Perreault, C. Immunogenetics (2002) [Pubmed]
  4. Effect of a metalloproteinase inhibitor on established corneal ulcers after an alkali burn. Wentworth, J.S., Paterson, C.A., Gray, R.D. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  5. Determination of left ventricular ejection fraction using intravenous contrast and a semiautomated border detection algorithm. Yu, E.H., Skyba, D.M., Sloggett, C.E., Jamorski, M., Iwanochko, R.M., Dias, B.F., Rakowski, H., Siu, S.C. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (2003) [Pubmed]
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