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Gene Review

STT3A  -  STT3A, subunit of the oligosaccharyltransf...

Homo sapiens

Synonyms: B5, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, ITM1, Integral membrane protein 1, MGC9042, ...
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Disease relevance of STT3A

  • A PB module of subclass B2 or B3 is linked to an n-PB module of subclass B2 or B3 in gram-negative bacteria, and a PB module of subclass B1, B4, or B5 is linked to an n-PB module of subclass B1, B4, or B5 in gram-positive bacteria [1].
  • Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases [2].
  • Prior incubation of membranes with pertussis toxin blocked R37A or TMC inhibition of cAMP production [3].
  • Immunization of B10.PL mice with a recombinant adenovirus expressing the TCR Vbeta8.2 chain (Ad5E1 mVbeta8.2), resulted in induction of regulatory type 1 CD4 T cells, directed against the framework region 3 determinant within the B5 peptide (aa 76-101) of the Vbeta8.2 chain [4].
  • An open-label assessment of TMC 125--a new, next-generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance [5].

High impact information on STT3A


Chemical compound and disease context of STT3A


Biological context of STT3A


Anatomical context of STT3A

  • The human homolog of B5 was isolated from a cDNA testis library [16].
  • Integral membrane proteins of the endoplasmic reticulum are ubiquitinated and destroyed by the proteasome [17].
  • Integral membrane proteins are visualized as intramembrane particles (IMP; also called membrane-associated particles) at the cleaved surfaces of freeze-fractured plasma membranes [18].
  • A significant proportion (31.8+/-7.9% in TMC and 25.8+/-9.7% in AMC) of the apoptotic tumour cells within tumour nests were in close contact with CD3(+) lymphocytes [19].
  • The gene, designated hfl-B5, encodes a type II cell surface membrane protein, B5, that is broadly expressed in human primary tissue and cell lines [20].

Associations of STT3A with chemical compounds

  • Integral membrane heparan sulfate proteoglycans [21].
  • Integral membrane proteins often contain proline residues in their alpha-helical transmembrane (TM) fragments, which may strongly influence their folding and association [22].
  • The choline homologue 3-[(trimethylammonio)methyl]catechol (TMC) has been synthesized, and the controllable features of its complex oxidation have been examined spectroscopically and correlated with its toxin binding inactivating reactions with the acetylcholine receptor (AcChR) from Torpedo californica electroplax [23].
  • Integral membrane proteins are characterized by having a preference for aromatic residues, e.g., tryptophan (W), at the interface between the lipid bilayer core and the aqueous phase [24].
  • At pH 7.4, where the oxidative polymerization of catechols proceeds spontaneously, pyrocatechol produced no effect on the toxin binding function of AcChR, whereas comparable concentrations of TMC led to inactivation of half of all available sites [23].

Other interactions of STT3A


Analytical, diagnostic and therapeutic context of STT3A

  • The TMC Worldwide Gene Therapy Enrollment Report, end 1996 [27].
  • CONCLUSIONS: We improved this diagnostic test by adding C1orf24 and ITM1 custom antibodies and showing use on a wider variety of thyroid pathology [28].
  • In a previous study of 131 breast carcinomas with medullary features, we evaluated the diagnostic inter- and intraobserver variation and its prognostic implications using the criteria of typical (TMC) and atypical (AMC) medullary carcinoma of the breast put forward by Ridolfi et al [29].
  • Integral membrane proteins and lipids from human red cells were fractionated in the presence of octyl glucoside by high-performance gel chromatography on a 22-ml column of the small-bead cross-linked agarose gel Superose 6, at 5 degrees C, pH 7.6 and 30-50 mM detergent [30].
  • OBJECTIVE: To assess the performance and clinical value of the postwash total motile sperm count (postwash TMC) as a test to predict intrauterine insemination (IUI) outcome [31].


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  12. High-dose topotecan, melphalan, and cyclophosphamide (TMC) with stem cell support: a new regimen for the treatment of advanced ovarian cancer. Donato, M.L., Gershenson, D.M., Wharton, J.T., Ippoliti, C.M., Aleman, A.S., Bodurka-Bevers, D., Bevers, M.W., Burke, T.W., Levenback, C.F., Wolf, J.K., Freedman, R.S., Bast, R.C., Gajewski, J.L., Champlin, R.E. Gynecol. Oncol. (2001) [Pubmed]
  13. A reanalysis of liver cancer incidence in Danish patients administered thorotrast using a two-mutation carcinogenesis model. Leenhouts, H.P., Brugmans, M.J., Andersson, M., Storm, H.H. Radiat. Res. (2002) [Pubmed]
  14. A dose-ranging study to evaluate the beta 1-adrenoceptor selectivity of bisoprolol. Lipworth, B.J., Irvine, N.A., McDevitt, D.G. Eur. J. Clin. Pharmacol. (1991) [Pubmed]
  15. Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. Kawase, M., Hashimoto, H., Hosoda, M., Morita, H., Hosono, A. J. Dairy Sci. (2000) [Pubmed]
  16. Molecular cloning of a highly conserved mouse and human integral membrane protein (Itm1) and genetic mapping to mouse chromosome 9. Hong, G., Deleersnijder, W., Kozak, C.A., Van Marck, E., Tylzanowski, P., Merregaert, J. Genomics (1996) [Pubmed]
  17. Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins. Hicke, L. FASEB J. (1997) [Pubmed]
  18. Changes in plasma membrane structure associated with malignant transformation in human urinary bladder epithelium. Weinstein, R.S. Cancer Res. (1976) [Pubmed]
  19. Apoptosis, proliferation, and Fas (APO-1, CD95)/Fas ligand expression in medullary carcinoma of the breast. Yakirevich, E., Maroun, L., Cohen, O., Izhak, O.B., Rennert, G., Resnick, M.B. J. Pathol. (2000) [Pubmed]
  20. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. Perez, A., Li, Q.X., Perez-Romero, P., Delassus, G., Lopez, S.R., Sutter, S., McLaren, N., Fuller, A.O. J. Virol. (2005) [Pubmed]
  21. Integral membrane heparan sulfate proteoglycans. David, G. FASEB J. (1993) [Pubmed]
  22. Influence of proline residues in transmembrane helix packing. Orzáez, M., Salgado, J., Giménez-Giner, A., Pérez-Payá, E., Mingarro, I. J. Mol. Biol. (2004) [Pubmed]
  23. Affinity-dependent cross-linking to neurotoxin sites of the acetylcholine receptor mediated by catechol oxidation. Nickoloff, B.J., Grimes, M., Wohlfeil, E., Hudson, R.A. Biochemistry (1985) [Pubmed]
  24. Interfacial tryptophan residues: a role for the cation-pi effect? Petersen, F.N., Jensen, M.Ø., Nielsen, C.H. Biophys. J. (2005) [Pubmed]
  25. Assignment of the human integral transmembrane protein 1 gene (ITM1) to human chromosome band 11q23.3 by in situ hybridization and YAC mapping. Van Hul, W., Hong, G., Wauters, J., Van Hul, E., Nowak, N., Shows, T.B., Willems, P.J., Merregaert, J. Cytogenet. Cell Genet. (1996) [Pubmed]
  26. Identification of two distinct intracellular localization signals in STT3-B. Caron, E., Côté, C., Parisien, M., Major, F., Perreault, C. Arch. Biochem. Biophys. (2006) [Pubmed]
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  28. Diagnosis of suspicious thyroid nodules using four protein biomarkers. Cerutti, J.M., Latini, F.R., Nakabashi, C., Delcelo, R., Andrade, V.P., Amadei, M.J., Maciel, R.M., Hojaij, F.C., Hollis, D., Shoemaker, J., Riggins, G.J. Clin. Cancer Res. (2006) [Pubmed]
  29. Medullary carcinoma of the breast, proposal for a new simplified histopathological definition. Based on prognostic observations and observations on inter- and intraobserver variability of 11 histopathological characteristics in 131 breast carcinomas with medullary features. Pedersen, L., Zedeler, K., Holck, S., Schiødt, T., Mouridsen, H.T. Br. J. Cancer (1991) [Pubmed]
  30. High-performance agarose gel chromatography in octyl glucoside of integral membrane proteins from human red cells, with special reference to the glucose transporter. Mascher, E., Lundahl, P. J. Chromatogr. (1987) [Pubmed]
  31. Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: a meta-analysis. van Weert, J.M., Repping, S., Van Voorhis, B.J., van der Veen, F., Bossuyt, P.M., Mol, B.W. Fertil. Steril. (2004) [Pubmed]
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