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Gene Review

STT3  -  dolichyl-diphosphooligosaccharide--protein...

Saccharomyces cerevisiae S288c

Synonyms: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3, Oligosaccharyl transferase subunit STT3, YGL022W
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High impact information on STT3

  • As no significant nascent chain photocross-linking to other OST subunits was detected in these fully assembled translocation and integration intermediates, our results strongly indicate that the nascent chain portion of the OST active site is located in STT3 [1].
  • A mutation in the STT3 locus affects substrate specificity of the OTase complex in vivo and in vitro [2].
  • The essential STT3 protein is approximately 60% identical in amino acid sequence to its human homologue [2].
  • The highly conserved membrane protein STT3 is part of the oligosaccharyl transferase complex in the endoplasmic reticulum of eukaryotic cells [3].
  • Staurosporine is a specific inhibitor of Pkc1p, and a genetic link had previously been suggested between PKC1 and STT3 [4].

Biological context of STT3


Analytical, diagnostic and therapeutic context of STT3

  • When translocation intermediates with nascent chains of increasing length were irradiated, nascent chain photocross-linking to translocon components, Sec61alpha and TRAM, was replaced by efficient photocross-linking solely to a protein identified by immunoprecipitation as the STT3 subunit of the OST [1].


  1. Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex. Nilsson, I., Kelleher, D.J., Miao, Y., Shao, Y., Kreibich, G., Gilmore, R., von Heijne, G., Johnson, A.E. J. Cell Biol. (2003) [Pubmed]
  2. STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo. Zufferey, R., Knauer, R., Burda, P., Stagljar, I., te Heesen, S., Lehle, L., Aebi, M. EMBO J. (1995) [Pubmed]
  3. Membrane topology of the STT3 subunit of the oligosaccharyl transferase complex. Kim, H., von Heijne, G., Nilsson, I. J. Biol. Chem. (2005) [Pubmed]
  4. Insight into functional aspects of Stt3p, a subunit of the oligosaccharyl transferase. Evidence for interaction of the N-terminal domain of Stt3p with the protein kinase C cascade. Chavan, M., Rekowicz, M., Lennarz, W. J. Biol. Chem. (2003) [Pubmed]
  5. The STT3 protein is a component of the yeast oligosaccharyltransferase complex. Spirig, U., Glavas, M., Bodmer, D., Reiss, G., Burda, P., Lippuner, V., te Heesen, S., Aebi, M. Mol. Gen. Genet. (1997) [Pubmed]
  6. STT3, a novel essential gene related to the PKC1/STT1 protein kinase pathway, is involved in protein glycosylation in yeast. Yoshida, S., Ohya, Y., Nakano, A., Anraku, Y. Gene (1995) [Pubmed]
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