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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Slc22a2  -  solute carrier family 22 (organic cation...

Mus musculus

Synonyms: Oct2, Orct2, Organic cation transporter 2, Solute carrier family 22 member 2
 
 
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High impact information on Slc22a2

  • Uptake of [(3)H]1-methyl-4-phenylpyridinium ([(3)H]MPP(+)) by Xenopus laevis oocytes injected with mOCT1 (Slc22a1) or mOCT2 (Slc22a2) cRNA was attenuated by an increase of extracellular K(+) concentration and under acidic extracellular conditions [1].
  • The results eliminate both Orct2 and Orct3 as candidates and further reduce the critical region containing the t(w73) mutant from 500 kb to 200 kb [2].
  • The genomic locus of the Orct2 gene appears similar in wild-type and t(w73) chromosomes [2].
  • Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus [3].

References

  1. Functional characterization of mouse cation transporter mOCT2 compared with mOCT1. Kakehi, M., Koyabu, N., Nakamura, T., Uchiumi, T., Kuwano, M., Ohtani, H., Sawada, Y. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Genetic analysis of the organic cation transporter genes Orct2/Slc22a2 and Orct3/Slc22a3 reduces the critical region for the t haplotype mutant t(w73) to 200 kb. Zwart, R., Verhaagh, S., de Jong, J., Lyon, M., Barlow, D.P. Mamm. Genome (2001) [Pubmed]
  3. Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus. Mooslehner, K.A., Allen, N.D. Mamm. Genome (1999) [Pubmed]
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