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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sntb1  -  syntrophin, basic 1

Mus musculus

Synonyms: 59 kDa dystrophin-associated protein A1 basic component 1, 59-1 DAP, Beta-1-syntrophin, DAPA1B, Snt2b1, ...
 
 
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High impact information on Sntb1

  • Using sequences derived from a new mouse beta1-syntrophin cDNA, and previously isolated cDNAs for alpha1- and beta2-syntrophins, we prepared isoform-specific antibodies to study the expression, skeletal muscle localization, and dystrophin family association of all three syntrophins [1].
  • We assigned Matn2 to mouse chromosome 15, linked to Trhr and Sntb1 in a region synthenic to human chromosome 8q22-24 [2].
  • Here, we show that biglycan null mice exhibit a mild dystrophic phenotype and display a selective reduction in the localization of alpha-dystrobrevin-1 and -2, alpha- and beta1-syntrophin, and nNOS at the sarcolemma [3].
  • We conclude that biglycan is important for the maintenance of muscle cell integrity and plays a direct role in regulating the expression and sarcolemmal localization of the intracellular signaling proteins dystrobrevin-1 and -2, alpha- and beta1-syntrophin and nNOS [3].

References

  1. Differential association of syntrophin pairs with the dystrophin complex. Peters, M.F., Adams, M.E., Froehner, S.C. J. Cell Biol. (1997) [Pubmed]
  2. Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices. Mátés, L., Korpos, E., Déak, F., Liu, Z., Beier, D.R., Aszódi, A., Kiss, I. Matrix Biol. (2002) [Pubmed]
  3. Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS. Mercado, M.L., Amenta, A.R., Hagiwara, H., Rafii, M.S., Lechner, B.E., Owens, R.T., McQuillan, D.J., Froehner, S.C., Fallon, J.R. FASEB J. (2006) [Pubmed]
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