Gene Review:
Trhr - thyrotropin releasing hormone receptor
Mus musculus
Synonyms:
TRH-R, TRH-R1, Thyroliberin receptor, Thyrotropin-releasing hormone receptor
- Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH. Wolff, G., Mastrangeli, A., Heinflink, M., Falck-Pedersen, E., Gershengorn, M.C., Crystal, R.G. Nat. Genet. (1996)
- Posttranscriptional up-regulation of thyrotropin-releasing hormone (TRH) receptor messenger ribonucleic acid by TRH in COS-1 cells transfected with mouse pituitary TRH receptor complementary deoxyribonucleic acid. Fujimoto, J., Narayanan, C.S., Benjamin, J.E., Gershengorn, M.C. Endocrinology (1992)
- Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Rabeler, R., Mittag, J., Geffers, L., Rüther, U., Leitges, M., Parlow, A.F., Visser, T.J., Bauer, K. Mol. Endocrinol. (2004)
- Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization. Yu, R., Hinkle, P.M. Mol. Endocrinol. (1998)
- Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect. Fujimoto, J., Straub, R.E., Gershengorn, M.C. Mol. Endocrinol. (1991)
- Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Straub, R.E., Frech, G.C., Joho, R.H., Gershengorn, M.C. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor. Jones, B.W., Hinkle, P.M. J. Biol. Chem. (2005)
- Regulation of thyrotropin-releasing hormone receptors is cell type specific: comparison of endogenous pituitary receptors and receptors transfected into non-pituitary cells. Gershengorn, M.C., Thaw, C.N. Endocrinology (1991)
- Thyrotropin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium. Perlman, J.H., Gershengorn, M.C. Endocrinology (1991)
- Structure, expression, and chromosomal localization of the mouse Atox1 gene. Hamza, I., Klomp, L.W., Gaedigk, R., White, R.A., Gitlin, J.D. Genomics (2000)
- Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices. Mátés, L., Korpos, E., Déak, F., Liu, Z., Beier, D.R., Aszódi, A., Kiss, I. Matrix Biol. (2002)
- Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cells. Narayanan, C.S., Fujimoto, J., Geras-Raaka, E., Gershengorn, M.C. J. Biol. Chem. (1992)
- Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11. Yu, R., Hinkle, P.M. J. Biol. Chem. (1999)
- Expression of thyrotropin-releasing hormone (TRH) receptor subtype 1 in mouse pancreatic islets and HIT-T15, an insulin-secreting clonal beta cell line. Yamada, M., Shibusawa, N., Hashida, T., Ozawa, A., Monden, T., Satoh, T., Mori, M. Life Sci. (2000)
- Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. Perlman, J.H., Thaw, C.N., Laakkonen, L., Bowers, C.Y., Osman, R., Gershengorn, M.C. J. Biol. Chem. (1994)
- A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Perlman, J.H., Laakkonen, L.J., Guarnieri, F., Osman, R., Gershengorn, M.C. Biochemistry (1996)
- Decreased levels of internalized thyrotropin-releasing hormone receptors after uncoupling from guanine nucleotide-binding protein and phospholipase-C. Nussenzveig, D.R., Heinflink, M., Gershengorn, M.C. Mol. Endocrinol. (1993)
- Localization of thyrotropin-releasing hormone receptor and thyrotroph embryonic factor on mouse chromosome 15. Lossie, A.C., Gordon, D.F., Camper, S.A. Mamm. Genome (1993)
- Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. Hanyaloglu, A.C., Seeber, R.M., Kohout, T.A., Lefkowitz, R.J., Eidne, K.A. J. Biol. Chem. (2002)
- A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. Collu, R., Tang, J., Castagné, J., Lagacé, G., Masson, N., Huot, C., Deal, C., Delvin, E., Faccenda, E., Eidne, K.A., Van Vliet, G. J. Clin. Endocrinol. Metab. (1997)
- Distribution of thyrotropin-releasing hormone receptor messenger RNA in the rat brain: an in situ hybridization study. Calzá, L., Giardino, L., Ceccatelli, S., Zanni, M., Elde, R., Hökfelt, T. Neuroscience (1992)