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Trhr  -  thyrotropin releasing hormone receptor

Mus musculus

Synonyms: TRH-R, TRH-R1, Thyroliberin receptor, Thyrotropin-releasing hormone receptor
 
 
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Disease relevance of Trhr

 

High impact information on Trhr

  • The ectopically expressed TRHR links to the phosphoinositide pathway, providing a means to regulate liver function with TRH, an extracellular ligand that does not normally affect hepatic function [1].
  • Using Xenopus laevis oocytes in an expression cloning strategy, we have isolated a cDNA clone that encodes the mouse pituitary TRH-R [6].
  • Binding sites for TRH are present in these tissues, but the TRH receptor (TRH-R) has not been purified from any source [6].
  • The 3.8-kilobase mouse TRH-R cDNA encodes a protein of 393 amino acids that shows similarities to other guanine nucleotide-binding regulatory protein-coupled receptors [6].
  • Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor [7].
 

Chemical compound and disease context of Trhr

 

Biological context of Trhr

 

Anatomical context of Trhr

 

Associations of Trhr with chemical compounds

 

Physical interactions of Trhr

  • These data support the idea that a quaternary complex of TRH/TRH-R/G protein/PLC is normally internalized [17].
 

Regulatory relationships of Trhr

  • Since TRH and PMA down-regulate TRH-R mRNA in GH3 cells, posttranscriptional regulation of TRH-R mRNA is a cell-type specific process [2].
  • However, it still remains unclear whether TRH receptor is expressed in the pancreas [14].
 

Other interactions of Trhr

 

Analytical, diagnostic and therapeutic context of Trhr

References

  1. Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH. Wolff, G., Mastrangeli, A., Heinflink, M., Falck-Pedersen, E., Gershengorn, M.C., Crystal, R.G. Nat. Genet. (1996) [Pubmed]
  2. Posttranscriptional up-regulation of thyrotropin-releasing hormone (TRH) receptor messenger ribonucleic acid by TRH in COS-1 cells transfected with mouse pituitary TRH receptor complementary deoxyribonucleic acid. Fujimoto, J., Narayanan, C.S., Benjamin, J.E., Gershengorn, M.C. Endocrinology (1992) [Pubmed]
  3. Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Rabeler, R., Mittag, J., Geffers, L., Rüther, U., Leitges, M., Parlow, A.F., Visser, T.J., Bauer, K. Mol. Endocrinol. (2004) [Pubmed]
  4. Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization. Yu, R., Hinkle, P.M. Mol. Endocrinol. (1998) [Pubmed]
  5. Thyrotropin-releasing hormone (TRH) and phorbol myristate acetate decrease TRH receptor messenger RNA in rat pituitary GH3 cells: evidence that protein kinase-C mediates the TRH effect. Fujimoto, J., Straub, R.E., Gershengorn, M.C. Mol. Endocrinol. (1991) [Pubmed]
  6. Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Straub, R.E., Frech, G.C., Joho, R.H., Gershengorn, M.C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  7. Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor. Jones, B.W., Hinkle, P.M. J. Biol. Chem. (2005) [Pubmed]
  8. Regulation of thyrotropin-releasing hormone receptors is cell type specific: comparison of endogenous pituitary receptors and receptors transfected into non-pituitary cells. Gershengorn, M.C., Thaw, C.N. Endocrinology (1991) [Pubmed]
  9. Thyrotropin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium. Perlman, J.H., Gershengorn, M.C. Endocrinology (1991) [Pubmed]
  10. Structure, expression, and chromosomal localization of the mouse Atox1 gene. Hamza, I., Klomp, L.W., Gaedigk, R., White, R.A., Gitlin, J.D. Genomics (2000) [Pubmed]
  11. Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices. Mátés, L., Korpos, E., Déak, F., Liu, Z., Beier, D.R., Aszódi, A., Kiss, I. Matrix Biol. (2002) [Pubmed]
  12. Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cells. Narayanan, C.S., Fujimoto, J., Geras-Raaka, E., Gershengorn, M.C. J. Biol. Chem. (1992) [Pubmed]
  13. Signal transduction and hormone-dependent internalization of the thyrotropin-releasing hormone receptor in cells lacking Gq and G11. Yu, R., Hinkle, P.M. J. Biol. Chem. (1999) [Pubmed]
  14. Expression of thyrotropin-releasing hormone (TRH) receptor subtype 1 in mouse pancreatic islets and HIT-T15, an insulin-secreting clonal beta cell line. Yamada, M., Shibusawa, N., Hashida, T., Ozawa, A., Monden, T., Satoh, T., Mori, M. Life Sci. (2000) [Pubmed]
  15. Hydrogen bonding interaction of thyrotropin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. Perlman, J.H., Thaw, C.N., Laakkonen, L., Bowers, C.Y., Osman, R., Gershengorn, M.C. J. Biol. Chem. (1994) [Pubmed]
  16. A refined model of the thyrotropin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Perlman, J.H., Laakkonen, L.J., Guarnieri, F., Osman, R., Gershengorn, M.C. Biochemistry (1996) [Pubmed]
  17. Decreased levels of internalized thyrotropin-releasing hormone receptors after uncoupling from guanine nucleotide-binding protein and phospholipase-C. Nussenzveig, D.R., Heinflink, M., Gershengorn, M.C. Mol. Endocrinol. (1993) [Pubmed]
  18. Localization of thyrotropin-releasing hormone receptor and thyrotroph embryonic factor on mouse chromosome 15. Lossie, A.C., Gordon, D.F., Camper, S.A. Mamm. Genome (1993) [Pubmed]
  19. Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. Hanyaloglu, A.C., Seeber, R.M., Kohout, T.A., Lefkowitz, R.J., Eidne, K.A. J. Biol. Chem. (2002) [Pubmed]
  20. A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. Collu, R., Tang, J., Castagné, J., Lagacé, G., Masson, N., Huot, C., Deal, C., Delvin, E., Faccenda, E., Eidne, K.A., Van Vliet, G. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  21. Distribution of thyrotropin-releasing hormone receptor messenger RNA in the rat brain: an in situ hybridization study. Calzá, L., Giardino, L., Ceccatelli, S., Zanni, M., Elde, R., Hökfelt, T. Neuroscience (1992) [Pubmed]
 
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