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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

spc  -  sparse coat

Mus musculus

 
 
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High impact information on spc

  • Here we show that IL-12 activates an anti-angiogenic program in Con A-activated mouse spleen cells (activated spc) or human PBMC (activated PBMC) [1].
  • Experiments with nu/nu mice, nonobese diabetic-SCID mice, or activated spc enriched in specific cell subpopulations demonstrated that CD4(+), CD8(+), and NK cells are all needed to mediate the full anti-angiogenetic effect of IL-12 [1].
  • The resulting fragments were cloned into the pGL 3-vector and analysed for reporter gene activity in the murine germ cell lines GC-1 spg and GC-4 spc, leading to the characterization of a core promoter (--159 to--1), an enhancing region (--673 to--364) and a silencing region (--1262 to--669) [2].

References

  1. IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk. Strasly, M., Cavallo, F., Geuna, M., Mitola, S., Colombo, M.P., Forni, G., Bussolino, F. J. Immunol. (2001) [Pubmed]
  2. Characterization of a human TSPY promoter. Skawran, B., Schubert, S., Dechend, F., Vervoorts, J., Nayernia, K., Lüscher, B., Schmidtke, J. Mol. Cell. Biochem. (2005) [Pubmed]
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