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Gene Review

Sephs2  -  selenophosphate synthetase 2

Mus musculus

Synonyms: Selenide, water dikinase 2, Selenium donor protein 2, Selenophosphate synthase 2, Sps2, Ysg3
 
 
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Disease relevance of Sephs2

 

High impact information on Sephs2

  • Fetal mouse selenophosphate synthetase 2 (SPS2): characterization of the cysteine mutant form overproduced in a baculovirus-insect cell system [2].
  • Using an N-FLAG monoclonal antibody, it was shown that the full length N-FLAG-sps2 gene product was expressed in COS-7 cells [1].
  • These results confirm that the mouse embryonic sps2 gene encodes an eukaryotic selenophosphate synthetase, and that availability of selenophosphate as a selenium donor compound is widespread [1].

References

  1. Fetal mouse selenophosphate synthetase 2 (SPS2): biological activities of mutant forms in Escherichia coli. Kim, T.S., Yu, M.H., Chung, Y.W., Kim, J., Choi, E.J., Ahn, K., Kim, I.Y. Mol. Cells (1999) [Pubmed]
  2. Fetal mouse selenophosphate synthetase 2 (SPS2): characterization of the cysteine mutant form overproduced in a baculovirus-insect cell system. Kim, I.Y., Guimarães, M.J., Zlotnik, A., Bazan, J.F., Stadtman, T.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
 
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