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Gene Review:

Spt1 - salivary protein 1

Mus musculus

Synonyms: 16.5 kDa submandibular gland glycoprotein, Salivary protein 1, Spt-1

Cha, S. et al., Bekhor, I. et al., de Wilde, P.C. et al., Raimondi, A.R. et al., Nishiyama, T. et al., et al.

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Disease relevance of Spt1

OBJECTIVE: Salivary glands of patients with Sjögren's syndrome (SS) have been shown to be a site of anti-SS-B/La antibody production [1].
Rapid Development of Salivary Gland Carcinomas upon Conditional Expression of K-ras Driven by the Cytokeratin 5 Promoter [2].

High impact information on Spt1

1. Salivary acini were isolated enzymatically from submandibular glands of adult male mice [3].
Up-Regulated PAR-2-Mediated Salivary Secretion in Mice Deficient in Muscarinic Acetylcholine Receptor Subtypes [4].
OBJECTIVES: Salivary gland organogenesis was evaluated in NOD mice, an animal model for autoimmune exocrinopathy, to determine when disease onset is first present in the target tissues [5].
However, the amino acid sequence of p20 suggests that it may be from a gene or gene family homologous to rat common salivary protein 1 [6].
In contrast to Spt-1, the Spt-2 gene is not expressed at detectable levels in the lacrimal gland [7].

References

Aberrant expression pattern of the SS-B/La antigen in the labial salivary glands of patients with Sjögren's syndrome. de Wilde, P.C., Kater, L., Bodeutsch, C., van den Hoogen, F.H., van de Putte, L.B., van Venrooij, W.J. Arthritis Rheum. (1996) [Pubmed]
Rapid Development of Salivary Gland Carcinomas upon Conditional Expression of K-ras Driven by the Cytokeratin 5 Promoter. Raimondi, A.R., Vitale-Cross, L., Amornphimoltham, P., Gutkind, J.S., Molinolo, A. Am. J. Pathol. (2006) [Pubmed]
The receptor-regulated calcium influx in mouse submandibular acinar cells is sodium dependent: a patch-clamp study. Gallacher, D.V., Morris, A.P. J. Physiol. (Lond.) (1987) [Pubmed]
Up-Regulated PAR-2-Mediated Salivary Secretion in Mice Deficient in Muscarinic Acetylcholine Receptor Subtypes. Nishiyama, T., Nakamura, T., Obara, K., Inoue, H., Mishima, K., Matsumoto, N., Matsui, M., Manabe, T., Mikoshiba, K., Saito, I. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy. Cha, S., van Blockland, S.C., Versnel, M.A., Homo-Delarche, F., Nagashima, H., Brayer, J., Peck, A.B., Humphreys-Beher, M.G. Exp. Clin. Immunogenet. (2001) [Pubmed]
cDNA cloning, sequencing and in situ localization of a transcript specific to both sublingual demilune cells and parotid intercalated duct cells in mouse salivary glands. Bekhor, I., Wen, Y., Shi, S., Hsieh, C.H., Denny, P.A., Denny, P.C. Arch. Oral Biol. (1994) [Pubmed]
Genetic and tissue-specific variation in the expression of a closely linked murine multigene family on chromosome 15 that encodes salivary and lacrimal proteins. Dickinson, D.P., Abel, K., Near, J., Taylor, B.A., Gross, K.W. Biochem. Genet. (1989) [Pubmed]

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