Disease relevance of ERH

• The human gene coding for the enhancer of rudimentary homologue (ERH) protein was overexpressed in Escherichia coli [1].

High impact information on ERH

• Intriguingly, both the PRMT5 and ERH proteins are interacting partners of the SPT5 elongation factor [2].
• The human cDNA, termed ERH, consists of 797 nucleotides, which include an open reading frame of 312 nucleotides encoding 104 amino acids [3].
• Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene [3].

Analytical, diagnostic and therapeutic context of ERH

• We assigned the ERH gene locus to chromosomal band 7q34 by fluorescence in situ hybridization [3].
• The ERH protein was purified by anion-exchange, hydrophobic interaction and gel-filtration chromatography [1].
• Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human transcription repressor ERH [1].

References