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Gene Review

Creb3l3  -  cAMP responsive element binding protein 3...

Mus musculus

Synonyms: BC010786, CREB-H, Crebh, Cyclic AMP-responsive element-binding protein 3-like protein 3, D10Bur1e, ...
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Disease relevance of Creb3l3

  • Here, we identified CREBH as a RIP-regulated liver-specific transcription factor that is cleaved upon ER stress and required to activate expression of acute phase response (APR) genes [1].
  • The enforced expression of CREB-H suppresses the proliferation of cultured hepatoma cells [2].

High impact information on Creb3l3


Regulatory relationships of Creb3l3


  1. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D.T., Back, S.H., Kaufman, R.J. Cell (2006) [Pubmed]
  2. The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma. Chin, K.T., Zhou, H.J., Wong, C.M., Lee, J.M., Chan, C.P., Qiang, B.Q., Yuan, J.G., Ng, I.O., Jin, D.Y. Nucleic Acids Res. (2005) [Pubmed]
  3. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Luebke-Wheeler, J., Zhang, K., Battle, M., Si-Tayeb, K., Garrison, W., Chhinder, S., Li, J., Kaufman, R.J., Duncan, S.A. Hepatology. (2008) [Pubmed]
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