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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Il1f9  -  interleukin 1 family, member 9

Mus musculus

Synonyms: IL-1F9, Il36g, Interleukin-1 family member 9, Interleukin-36 gamma
 
 
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High impact information on Il1f9

  • However, IL-1F9 failed to induce any of the classical IL-1beta responses, suggesting that it may trigger alternative pathway(s) [1].
  • IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells [1].
  • Our results exclude Il1rn as the gene for Abhr1 and indicate that Il1f9 warrants further investigation based on genetic and expression differences observed in our mouse model of allergic asthma [2].
  • Of these, only Il1f9 is located within Abhr1, and we found several non-coding polymorphisms in the Il1f9 gene between A/J and C3H/HeJ mice [2].
 

Anatomical context of Il1f9

  • These results demonstrate that glial cells may be a target for the new ligand IL-1F9, since high expression of IL-1Rrp2 mRNA was detected in these cells [1].
 

Other interactions of Il1f9

  • The aim of the present study was therefore to investigate expression of IL-1Rrp2 and to determine if IL-1F9 induces known IL-1 signaling pathways in the different cell types of the mouse brain in culture [1].

References

  1. IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells. Berglöf, E., Andre, R., Renshaw, B.R., Allan, S.M., Lawrence, C.B., Rothwell, N.J., Pinteaux, E. J. Neuroimmunol. (2003) [Pubmed]
  2. IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma. Ramadas, R.A., Li, X., Shubitowski, D.M., Samineni, S., Wills-Karp, M., Ewart, S.L. Immunogenetics (2006) [Pubmed]
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