Gene Review:
Il1b - interleukin 1 beta
Mus musculus
Synonyms:
IL-1 beta, IL-1B, IL-1beta, Il-1b, Interleukin-1 beta
- Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Lu, J.Y., Sadri, N., Schneider, R.J. Genes Dev. (2006)
- Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis. Friedlander, R.M., Gagliardini, V., Rotello, R.J., Yuan, J. J. Exp. Med. (1996)
- Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth. Nakao, S., Kuwano, T., Tsutsumi-Miyahara, C., Ueda, S., Kimura, Y.N., Hamano, S., Sonoda, K.H., Saijo, Y., Nukiwa, T., Strieter, R.M., Ishibashi, T., Kuwano, M., Ono, M. J. Clin. Invest. (2005)
- Interferon-gamma, Staphylococcus aureus, and lipopolysaccharide/silica enhance interleukin-1 beta production by human corneal cells. Shams, N.B., Sigel, M.M., Davis, R.M. Regional immunology. (1989)
- Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection. Noorbakhsh, F., Vergnolle, N., McArthur, J.C., Silva, C., Vodjgani, M., Andrade-Gordon, P., Hollenberg, M.D., Power, C. J. Immunol. (2005)
- Advanced glycation endproducts and pro-inflammatory cytokines in transgenic Tg2576 mice with amyloid plaque pathology. Münch, G., Apelt, J., Rosemarie-Kientsch-Engel, n.u.l.l., Stahl, P., Lüth, H.J., Schliebs, R. J. Neurochem. (2003)
- Endogenous Interleukin (IL)-1 alpha and IL-1 beta Are Crucial for Host Defense against Disseminated Candidiasis. Vonk, A.G., Netea, M.G., van Krieken, J.H., Iwakura, Y., van der Meer, J.W., Kullberg, B.J. J. Infect. Dis. (2006)
- Defect in interleukin-1beta secretion prevents sickness behavior in C3H/HeJ mice. Segreti, J., Gheusi, G., Dantzer, R., Kelley, K.W., Johnson, R.W. Physiol. Behav. (1997)
- Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Martinon, F., Tschopp, J. Cell (2004)
- Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., Yuan, J. Cell (1998)
- Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., McDowell, J., Paskind, M., Rodman, L., Salfeld, J. Cell (1995)
- MyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta. Ogimoto, K., Harris, M.K., Wisse, B.E. Endocrinology (2006)
- Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. Sävendahl, L., Underwood, L.E., Haldeman, K.M., Ulshen, M.H., Lund, P.K. Endocrinology (1997)
- Cytokines in Parkinson's disease. Nagatsu, T., Mogi, M., Ichinose, H., Togari, A. J. Neural Transm. Suppl. (2000)
- Mycobacterial cell wall components induce the production of TNF-alpha, IL-1, and IL-6 by bovine monocytes and the murine macrophage cell line RAW 264.7. Adams, J.L., Czuprynski, C.J. Microb. Pathog. (1994)
- Actinobacillus actinomycetemcomitans lipopolysaccharide induces interleukin-6 expression through multiple mitogen-activated protein kinase pathways in periodontal ligament fibroblasts. Patil, C., Rossa, C., Kirkwood, K.L. Oral Microbiol. Immunol. (2006)
- Variation in IL-1beta gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. Ohmura, K., Johnsen, A., Ortiz-Lopez, A., Desany, P., Roy, M., Besse, W., Rogus, J., Bogue, M., Puech, A., Lathrop, M., Mathis, D., Benoist, C. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Quantitative gene expression profiling implicates genes for susceptibility and resistance to alveolar bone loss. Hart, G.T., Shaffer, D.J., Akilesh, S., Brown, A.C., Moran, L., Roopenian, D.C., Baker, P.J. Infect. Immun. (2004)
- Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. Ueda, Y., Yang, K., Foster, S.J., Kondo, M., Kelsoe, G. J. Exp. Med. (2004)
- Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Kuida, K., Lippke, J.A., Ku, G., Harding, M.W., Livingston, D.J., Su, M.S., Flavell, R.A. Science (1995)
- Cytokine gene expression in murine epidermal cell suspensions: interleukin 1 beta and macrophage inflammatory protein 1 alpha are selectively expressed in Langerhans cells but are differentially regulated in culture. Heufler, C., Topar, G., Koch, F., Trockenbacher, B., Kämpgen, E., Romani, N., Schuler, G. J. Exp. Med. (1992)
- Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme. Molineaux, S.M., Casano, F.J., Rolando, A.M., Peterson, E.P., Limjuco, G., Chin, J., Griffin, P.R., Calaycay, J.R., Ding, G.J., Yamin, T.T. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Nitric oxide synthase is induced in tumor promoter-sensitive, but not tumor promoter-resistant, JB6 mouse epidermal cells cocultured with interferon-gamma-stimulated RAW 264.7 cells: the role of tumor necrosis factor-alpha. Murakami, A., Kawabata, K., Koshiba, T., Gao, G., Nakamura, Y., Koshimizu, K., Ohigashi, H. Cancer Res. (2000)
- In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Chensue, S.W., Terebuh, P.D., Remick, D.G., Scales, W.E., Kunkel, S.L. Am. J. Pathol. (1991)
- Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways. Hsu, H.Y., Chiu, S.L., Wen, M.H., Chen, K.Y., Hua, K.F. J. Biol. Chem. (2001)
- The role of p38 mitogen-activated protein kinase in IL-1 beta transcription. Baldassare, J.J., Bi, Y., Bellone, C.J. J. Immunol. (1999)
- Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice. Reznikov, L.L., Shames, B.D., Barton, H.A., Selzman, C.H., Fantuzzi, G., Kim, S.H., Johnson, S.M., Dinarello, C.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2000)
- Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1 beta in mouse cultured mast cells. Ashraf, M., Murakami, M., Kudo, I. Biochem. J. (1996)
- IL-1beta epitope mapping using site-directed mutagenesis and hydrogen-deuterium exchange mass spectrometry analysis. Lu, J., Witcher, D.R., White, M.A., Wang, X., Huang, L., Rathnachalam, R., Beals, J.M., Kuhstoss, S. Biochemistry (2005)
- The role of neutral sphingomyelinase in interleukin-1beta signal transduction in mouse cerebral cortex cells. Rybakina, E.G., Nalivaeva, N.N., Pivanovich, Y.U., Shanin, S.N., Kozinets, A., Korneva, E.A. Neurosci. Behav. Physiol. (2001)
- IL-1 beta increases laminin B2 chain mRNA levels and activates NF-kappa B in rat glomerular epithelial cells. Richardson, C.A., Gordon, K.L., Couser, W.G., Bomsztyk, K. Am. J. Physiol. (1995)
- Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model. Monack, D.M., Hersh, D., Ghori, N., Bouley, D., Zychlinsky, A., Falkow, S. J. Exp. Med. (2000)
- IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways. Yamamoto, T., Kojima, T., Murata, M., Takano, K., Go, M., Chiba, H., Sawada, N. Exp. Cell Res. (2004)
- Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice. Yao, C., Karabasil, M.R., Purwanti, N., Li, X., Akamatsu, T., Kanamori, N., Hosoi, K. J. Biol. Chem. (2006)
- Expression of neutral sphingomyelinase-2 (NSMase-2) in primary rat hepatocytes modulates IL-beta-induced JNK activation. Karakashian, A.A., Giltiay, N.V., Smith, G.M., Nikolova-Karakashian, M.N. FASEB J. (2004)
- BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages. Wessells, J., Baer, M., Young, H.A., Claudio, E., Brown, K., Siebenlist, U., Johnson, P.F. J. Biol. Chem. (2004)
- Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit ligand and interleukin-10 in mouse bone marrow-derived mast cells. Lu-Kuo, J.M., Austen, K.F., Katz, H.R. J. Biol. Chem. (1996)
- Pathogen-associated molecular patterns sensitize macrophages to Fas ligand-induced apoptosis and IL-1 beta release. Fukui, M., Imamura, R., Umemura, M., Kawabe, T., Suda, T. J. Immunol. (2003)
- CCAAT/enhancer-binding proteins beta and delta mediate the repression of gene transcription of cartilage-derived retinoic acid-sensitive protein induced by interleukin-1 beta. Okazaki, K., Li, J., Yu, H., Fukui, N., Sandell, L.J. J. Biol. Chem. (2002)
- Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. Qu, Y., Franchi, L., Nunez, G., Dubyak, G.R. J. Immunol. (2007)
- X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production. Filipe-Santos, O., Bustamante, J., Haverkamp, M.H., Vinolo, E., Ku, C.L., Puel, A., Frucht, D.M., Christel, K., von Bernuth, H., Jouanguy, E., Feinberg, J., Durandy, A., Senechal, B., Chapgier, A., Vogt, G., de Beaucoudrey, L., Fieschi, C., Picard, C., Garfa, M., Chemli, J., Bejaoui, M., Tsolia, M.N., Kutukculer, N., Plebani, A., Notarangelo, L., Bodemer, C., Geissmann, F., Israël, A., Véron, M., Knackstedt, M., Barbouche, R., Abel, L., Magdorf, K., Gendrel, D., Agou, F., Holland, S.M., Casanova, J.L. J. Exp. Med. (2006)
- IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1. Vidal-Vanaclocha, F., Fantuzzi, G., Mendoza, L., Fuentes, A.M., Anasagasti, M.J., Martín, J., Carrascal, T., Walsh, P., Reznikov, L.L., Kim, S.H., Novick, D., Rubinstein, M., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Didierlaurent, A., Brissoni, B., Velin, D., Aebi, N., Tardivel, A., Käslin, E., Sirard, J.C., Angelov, G., Tschopp, J., Burns, K. Mol. Cell. Biol. (2006)
- The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation. Galle, M., Schotte, P., Haegman, M., Wullaert, A., Yang, H.J., Jin, S., Beyaert, R. J. Cell. Mol. Med. (2008)
- Heat-shock protein 25 (Hspb1) regulates manganese superoxide dismutase through activation of Nfkb (NF-kappaB). Yi, M.J., Park, S.H., Cho, H.N., Yong Chung, H., Kim, J.I., Cho, C.K., Lee, S.J., Lee, Y.S. Radiat. Res. (2002)
- Interleukin-1 beta inhibits phospholamban gene expression in cultured cardiomyocytes. McTiernan, C.F., Lemster, B.H., Frye, C., Brooks, S., Combes, A., Feldman, A.M. Circ. Res. (1997)
- Apolipoprotein A-I inhibits the production of interleukin-1beta and tumor necrosis factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes. Hyka, N., Dayer, J.M., Modoux, C., Kohno, T., Edwards, C.K., Roux-Lombard, P., Burger, D. Blood (2001)
- Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. Wu, S., Boyer, C.M., Whitaker, R.S., Berchuck, A., Wiener, J.R., Weinberg, J.B., Bast, R.C. Cancer Res. (1993)
- In situ hybridization analysis of synovial and systemic cytokine messenger RNA expression in superantigen-mediated Staphylococcus aureus arthritis. Zhao, Y.X., Ljungdahl, A., Olsson, T., Tarkowski, A. Arthritis Rheum. (1996)