Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Abhr1 - antigen-induced bronchial...

Mus musculus

Ramadas, R.A. et al., Ewart, S.L. et al., Aoki-Nagase, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Abhr1

Furthermore, we identified two distinct quantitative trait loci (QTL) for susceptibility to allergen-induced AHR, Abhr1 (allergen-induced bronchial hyperresponsiveness) (lod = 4. 2) and Abhr2 (lod = 3.7), on chromosome 2 in backcross progeny from A/J and C3H/HeJ mice [1].
In the sensitized CGRP gene-disrupted mice, antigen-induced bronchial hyperresponsiveness was significantly attenuated compared with the sensitized wild-type mice [2].
The IL-1ra gene (Il1rn) maps near the allergen-induced bronchial hyper-responsiveness-1 locus, Abhr1, which we previously mapped to murine chromosome 2 using A/J (asthma susceptible) and C3H/HeJ (asthma resistant) mice [3].
Of these, only Il1f9 is located within Abhr1, and we found several non-coding polymorphisms in the Il1f9 gene between A/J and C3H/HeJ mice [3].

References

Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. Ewart, S.L., Kuperman, D., Schadt, E., Tankersley, C., Grupe, A., Shubitowski, D.M., Peltz, G., Wills-Karp, M. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice. Aoki-Nagase, T., Nagase, T., Oh-Hashi, Y., Shindo, T., Kurihara, Y., Yamaguchi, Y., Yamamoto, H., Tomita, T., Ohga, E., Nagai, R., Kurihara, H., Ouchi, Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
IL-1 Receptor antagonist as a positional candidate gene in a murine model of allergic asthma. Ramadas, R.A., Li, X., Shubitowski, D.M., Samineni, S., Wills-Karp, M., Ewart, S.L. Immunogenetics (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share