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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tead3  -  TEA domain family member 3

Mus musculus

Synonyms: AW125760, DTEF-1, ETF-related factor 1, ETFR-1, TEAD-3, ...
 
 
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High impact information on Tead3

  • Two of these genes, Hic-5, a possible negative regulator of muscle differentiation, and the transcription enhancing factor TEF-5 were selected and shown by in situ hybridizations to be expressed in the early developing heart [1].
  • Amino acid sequences deduced for ETFR-1 and -2 as well as those of other known proteins of the same family, TEF-1 and ETF, exhibited significant identity (63-75% overall) to each other not only in the TEA DNA binding domain but also in the C-terminal regions [2].
  • In this article, we describe the cDNA cloning and characterization of the murine TEA proteins DTEF-1 (mDTEF-1) and ETF [3].
  • Mouse DTEF-1 is expressed at a much lower level throughout development and is substantially enriched in ectoderm and skin, as well as in the developing pituitary at midgestation [3].

References

  1. Novel cell lines promote the discovery of genes involved in early heart development. Brunskill, E.W., Witte, D.P., Yutzey, K.E., Potter, S.S. Dev. Biol. (2001) [Pubmed]
  2. A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns. Yasunami, M., Suzuki, K., Ohkubo, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  3. cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors. Yockey, C.E., Shimizu, N. DNA Cell Biol. (1998) [Pubmed]
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