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Gene Review

Tead2  -  TEA domain family member 2

Mus musculus

Synonyms: ETEF-1, ETF, Embryonic TEA domain-containing factor, Etdf, Etf, ...
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Disease relevance of Tead2

  • The adenovirus oncoprotein E1a stimulates binding of transcription factor ETF to transcriptionally activate the p53 gene [1].

High impact information on Tead2


Biological context of Tead2


Anatomical context of Tead2

  • Immunostaining for Tead2 showed timed expression in myotube nuclei consistent with the mRNA data [8].
  • However, the expression of the ETF gene is strictly regulated in developing embryos and is limited to certain tissues, such as the hindbrain of a 10-day-old mouse embryo, in contrast to the ubiquitous expression pattern of the TEF-1 gene [6].
  • ETF is expressed throughout the embryo except in the myocardium early in development, whereas late in development, it is enriched in lung and neuroectoderm [9].
  • Northern blot analysis of adult mouse tissue total RNA showed that both ETF and mDTEF-1 are abundant in uterus and lung relative to other tissues [9].
  • Transcriptional enhancer factor-4 (TEF-4) enhances the transcription of CTalpha in COS-7 cells by interactions with the basal transcription machinery (Sugimoto, H., Bakovic, M., Yamashita, S., and Vance, D.E. (2001) J. Biol. Chem. 276,12338-12344) [10].

Other interactions of Tead2

  • Our data suggest a novel MyoD-Tead2-Fgfr4 pathway important for effective muscle regeneration [8].
  • Moreover, co-transfection of MyoD and Tead2 intron reporter constructs into 10T1/2 cells activated reporter activity in a dose-dependent manner [8].
  • Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEF-1) and is implicated in neural development [4].
  • In this article, we describe the cDNA cloning and characterization of the murine TEA proteins DTEF-1 (mDTEF-1) and ETF [9].
  • The binding of endogenous Ets-1 to the promoter probe was increased when TEF-4 was expressed; however, the amount of Ets-1 detected by immunoblotting was unchanged [10].

Analytical, diagnostic and therapeutic context of Tead2

  • Using gel mobility shift assays and GAL4-fusion protein analysis, we demonstrated that the full coding sequences of ETF and mDTEF-1 encode M-CAT/GT-IIC-binding proteins containing activation domains [9].


  1. The adenovirus oncoprotein E1a stimulates binding of transcription factor ETF to transcriptionally activate the p53 gene. Hale, T.K., Braithwaite, A.W. J. Biol. Chem. (1999) [Pubmed]
  2. DNA methylation may restrict but does not determine differential gene expression at the Sgy/Tead2 locus during mouse development. Kaneko, K.J., Rein, T., Guo, Z.S., Latham, K., DePamphilis, M.L. Mol. Cell. Biol. (2004) [Pubmed]
  3. Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Milewski, R.C., Chi, N.C., Li, J., Brown, C., Lu, M.M., Epstein, J.A. Development (2004) [Pubmed]
  4. Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene. Suzuki, K., Yasunami, M., Matsuda, Y., Maeda, T., Kobayashi, H., Terasaki, H., Ohkubo, H. Genomics (1996) [Pubmed]
  5. Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation. Hsu, D.K., Guo, Y., Alberts, G.F., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Peifley, K.A., Winkles, J.A. J. Biol. Chem. (1996) [Pubmed]
  6. Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells. Yasunami, M., Suzuki, K., Houtani, T., Sugimoto, T., Ohkubo, H. J. Biol. Chem. (1995) [Pubmed]
  7. Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region. Gómez, M., Manzano, A., Navarro-Sabaté, A., Duran, J., Obach, M., Perales, J.C., Bartrons, R. FEBS Lett. (2005) [Pubmed]
  8. Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway. Zhao, P., Caretti, G., Mitchell, S., McKeehan, W.L., Boskey, A.L., Pachman, L.M., Sartorelli, V., Hoffman, E.P. J. Biol. Chem. (2006) [Pubmed]
  9. cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors. Yockey, C.E., Shimizu, N. DNA Cell Biol. (1998) [Pubmed]
  10. Identification of Ets-1 as an important transcriptional activator of CTP:phosphocholine cytidylyltransferase alpha in COS-7 cells and co-activation with transcriptional enhancer factor-4. Sugimoto, H., Sugimoto, S., Tatei, K., Obinata, H., Bakovic, M., Izumi, T., Vance, D.E. J. Biol. Chem. (2003) [Pubmed]
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