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Gene Review

TEAD3  -  TEA domain family member 3

Homo sapiens

Synonyms: DTEF-1, ETFR-1, TEAD-3, TEAD5, TEF-5, ...
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Disease relevance of TEAD3

  • We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in skeletal and cardiac muscle, but the strongest expression is observed in the placenta and in placenta-derived JEG-3 choriocarcinoma cells [1].

High impact information on TEAD3

  • Taken together, these results suggest that DTEF-1 is a target for alpha(1)-adrenergic activation of the skeletal muscle alpha-actin gene in neonatal rat cardiac myocytes [2].
  • Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes [2].
  • These results strongly suggest that hTEF-5 regulates the activity of the hCS-B gene enhancer [1].
  • In the corresponding region of the hCS-A enhancer, which is known to be inactive, this element is inactivated by a naturally occurring single base mutation that disrupts hTEF-5 binding [1].
  • We define a novel functional element in this enhancer comprising tandemly repeated sites to which hTEF-5 binds cooperatively [1].

Biological context of TEAD3

  • Further, the data suggest that elements within the untranslated regions, initiation site, or both control TEF-5 expression in ways that influence its transactivation function [3].
  • The open reading frame of one 3033-bp clone was identical to TEF-5 and contained 300- and 1423-bp 5'- and 3'-untranslated regions, respectively [3].
  • Site-specific mutations in either the TEF-5 binding site or in the GATA binding site, each resulted in complete loss of enhancer activity [4].
  • The distinct spatial pattern of expression, and unusual amino acid sequence in its DNA binding domain, may indicate a particular role for DTEF-1 in cell-specific gene regulation [5].
  • Two isoforms of DTEF-1 (DTEF-1A and DTEF-1B) were isolated as 1.9-kilobase pair clones with putative open reading frames of 433 and 432 amino acids whose differences are attributable to alternative splicing at the C terminus of the TEA DNA binding domain [5].

Anatomical context of TEAD3

  • Cardiac muscle contains high levels of DTEF-1 transcripts, but unexpectedly low levels are detected in skeletal muscle [5].
  • DTEF-1 transcripts are present at intermediate levels in gizzard and lung, and at low levels in kidney [5].
  • A DTEF-1 peptide-specific antibody revealed that endogenous DTEF-1 accounts for up to 5% of the MCAT binding activity in neonatal rat cardiac myocytes [2].

Associations of TEAD3 with chemical compounds

  • The data indicate that TEF-5 and the GATA-like protein act in a coordinate manner to determine the placental-specific expression of the human 3betaHSD I enzyme and therefore are critical for placental progesterone production required for the maintenance of pregnancy [4].

Other interactions of TEAD3

  • The third class consists of a novel, divergent TEF-1 cDNA, named DTEF-1, and its preliminary characterization is described here [5].
  • DTEF-1 trans-activates the cTnT promoter in a tissue-specific fashion independent of AT-rich, MEF-2, or GATA sites [6].

Analytical, diagnostic and therapeutic context of TEAD3


  1. Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. Jacquemin, P., Martial, J.A., Davidson, I. J. Biol. Chem. (1997) [Pubmed]
  2. Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes. Maeda, T., Mazzulli, J.R., Farrance, I.K., Stewart, A.F. J. Biol. Chem. (2002) [Pubmed]
  3. Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer. Jiang, S.W., Wu, K., Eberhardt, N.L. Mol. Endocrinol. (1999) [Pubmed]
  4. Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1. Peng, L., Huang, Y., Jin, F., Jiang, S.W., Payne, A.H. Mol. Endocrinol. (2004) [Pubmed]
  5. DTEF-1, a novel member of the transcription enhancer factor-1 (TEF-1) multigene family. Azakie, A., Larkin, S.B., Farrance, I.K., Grenningloh, G., Ordahl, C.P. J. Biol. Chem. (1996) [Pubmed]
  6. Divergent transcriptional enhancer factor-1 regulates the cardiac troponin T promoter. Azakie, A., Lamont, L., Fineman, J.R., He, Y. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
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