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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ang4  -  angiogenin, ribonuclease A family, member 4

Mus musculus

Synonyms: Angiogenin-4, Raa4, Rnase5d
 
 
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Disease relevance of Ang4

  • Ang4 expression is induced by Bacteroides thetaiotaomicron, a predominant member of the gut microflora, revealing a mechanism whereby intestinal commensal bacteria influence gut microbial ecology and shape innate immunity [1].
 

High impact information on Ang4

  • We show that a previously uncharacterized angiogenin, Ang4, is produced by mouse Paneth cells, is secreted into the gut lumen and has bactericidal activity against intestinal microbes [1].
  • In vitro, we examined the effect of recombinant Ang-4 on endothelial cell migration in Boyden chambers [2].
  • In conclusion, we show that rhAng-4, as well as transfection with Ang-4, inhibits angiogenesis induced by GLC19 tumor cells and that Ang-4 expression reduces elevated tumor IFP [2].
  • Human umbilical vein endothelial cell (HUVEC) migration induced by bFGF and VEGF was inhibited by Ang-4 to control levels [2].

References

  1. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Hooper, L.V., Stappenbeck, T.S., Hong, C.V., Gordon, J.I. Nat. Immunol. (2003) [Pubmed]
  2. Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure. Olsen, M.W., Ley, C.D., Junker, N., Hansen, A.J., Lund, E.L., Kristjansen, P.E. Neoplasia (2006) [Pubmed]
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