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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Bacteroides


High impact information on Bacteroides

  • This means of generating surface diversity allows the organism to exhibit a wide array of distinct surface polysaccharide combinations, and may have broad implications for how the predominant human colonic microorganisms, the Bacteroides species, maintain an ecological niche in the intestinal tract [6].
  • Colonization of germ-free mice with Bacteroides thetaiotaomicron, a component of this flora, restored the fucosylation program, whereas an isogenic strain carrying a transposon insertion that disrupts its ability to use L-fucose as a carbon source did not [7].
  • Ang4 expression is induced by Bacteroides thetaiotaomicron, a predominant member of the gut microflora, revealing a mechanism whereby intestinal commensal bacteria influence gut microbial ecology and shape innate immunity [8].
  • The clinical significance of clindamycin-resistant Bacteroides fragilis [9].
  • Seven patients with infections including Bacteroides fragilis were treated with penicillin G, and all responded well [10].

Chemical compound and disease context of Bacteroides


Biological context of Bacteroides


Anatomical context of Bacteroides


Gene context of Bacteroides


Analytical, diagnostic and therapeutic context of Bacteroides

  • 43 specimens from a variety of sites were directly examined by indirect immunofluorescence assay (I.F.A.) with specific antisera against the capsular polysaccharide of Bacteroides fragilis and pooled antisera against a number of serotypes of Bacteroides sp. (all of the former B. fragilis subspecies) [29].
  • In four patients with continent ileostomy and malabsorption of B12, there was evidence of a stagnant loopsyndrome as oral lincomycin treatment resulted in increased absorption of B12 decreased excretion of faecal fat, and decreased concentrations of Bacteroides in the ileum [30].
  • The hemagglutinating factor (hemagglutinin) of Bacteroides gingivalis was prepared from the supernatant of a 5-day diffusate broth culture by ammonium sulfate precipitation and column chromatography with a hydrophobic column of Phenyl-Sepharose CL-4B, DEAE-Sephadex A-50, and Sephadex G-100 gel filtration [31].
  • The 747-bp cfiA gene, which encodes a metallo-beta-lactamase, and the regions flanking cfiA in six imipenem-resistant and four imipenem-susceptible Bacteroides fragilis strains isolated in Japan were analyzed by PCR and DNA sequencing [32].
  • However, cefoxitin provided serum and uterine concentrations above the minimum inhibitory concentration of Bacteroides fragilis for a longer period than did cefotaxime [33].


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  12. Simultaneous resistance to metronidazole, co-amoxiclav, and imipenem in clinical isolate of Bacteroides fragilis. Turner, P., Edwards, R., Weston, V., Gazis, A., Ispahani, P., Greenwood, D. Lancet (1995) [Pubmed]
  13. Clavulanic acid and susceptibility of Bacteroides fragilis to penicillin. Wise, R. Lancet (1977) [Pubmed]
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  16. Cellular immunity to Bacteroides fragilis capsular polysaccharide. Shapiro, M.E., Onderdonk, A.B., Kasper, D.L., Finberg, R.W. J. Exp. Med. (1982) [Pubmed]
  17. Transmembrane transcriptional control (surface signalling) of the Escherichia coli Fec type. Braun, V., Mahren, S. FEMS Microbiol. Rev. (2005) [Pubmed]
  18. Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70. Hoskins, L.C., Boulding, E.T., Larson, G. J. Biol. Chem. (1997) [Pubmed]
  19. Cloning and identification of a two-component signal-transducing regulatory system from Bacteroides fragilis. Rasmussen, B.A., Kovacs, E. Mol. Microbiol. (1993) [Pubmed]
  20. Effect of human colonic microsomes and cell-free extracts of Bacteroides fragilis on the mutagenicity of 2-aminoanthracene. Tasich, M., Piper, D.W. Gastroenterology (1983) [Pubmed]
  21. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Wu, S., Lim, K.C., Huang, J., Saidi, R.F., Sears, C.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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  23. Effect of molecular size on the ability of zwitterionic polysaccharides to stimulate cellular immunity. Kalka-Moll, W.M., Tzianabos, A.O., Wang, Y., Carey, V.J., Finberg, R.W., Onderdonk, A.B., Kasper, D.L. J. Immunol. (2000) [Pubmed]
  24. LPS regulation of the immune response: separate mechanisms for murine B cell activation by lipid A (direct) and polysaccharide (macrophage-dependent) derived from Bacteroides LPS. Williamson, S.I., Wannemuehler, M.J., Jirillo, E., Pritchard, D.G., Michalek, S.M., McGhee, J.R. J. Immunol. (1984) [Pubmed]
  25. DNA from probiotic bacteria modulates murine and human epithelial and immune function. Jijon, H., Backer, J., Diaz, H., Yeung, H., Thiel, D., McKaigney, C., De Simone, C., Madsen, K. Gastroenterology (2004) [Pubmed]
  26. Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides. Takada, H., Mihara, J., Morisaki, I., Hamada, S. Infect. Immun. (1991) [Pubmed]
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  28. Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Lorenz, E., Patel, D.D., Hartung, T., Schwartz, D.A. Infect. Immun. (2002) [Pubmed]
  29. Rapid diagnosis of Bacteroides infections by indirect immunofluorescence assay of clinical specimens. Kasper, D.L., Fiddian, A.P., Tabaqchali, S. Lancet (1979) [Pubmed]
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  31. Purification and properties of hemagglutinin from culture supernatant of Bacteroides gingivalis. Okuda, K., Yamamoto, A., Naito, Y., Takazoe, I., Slots, J., Genco, R.J. Infect. Immun. (1986) [Pubmed]
  32. New insertion sequence elements in the upstream region of cfiA in imipenem-resistant Bacteroides fragilis strains. Kato, N., Yamazoe, K., Han, C.G., Ohtsubo, E. Antimicrob. Agents Chemother. (2003) [Pubmed]
  33. Serum and tissue concentrations of cefoxitin and cefotaxime in women undergoing hysterectomy. White, R.L., Nightingale, C.H., Quintiliani, R., Whitaker, K.F., Jones, R.F., Tripp, W.H. Drugs (1988) [Pubmed]
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