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MeSH Review:

Immunity, Natural

Zhang, Y. et al., Schmitt, D. et al., Liu, Y.J., Rodriguez, M.A. et al., Mukae, N. et al., et al.

Raetz, Whitfield, Chu, Gong, Li, Takabayashi, Ouyang, Chen, Lois, Chen, Li, Karin, Raz, Liu, Applequist, Rollman, Wareing, Lidén, Rozell, Hinkula, Ljunggren, Fassbender, Walter, Kühl, Landmann, Ishii, Bertsch, Stalder, Muehlhauser, Liu, Ulmer, Rivest, Lentschat, Gulbins, Jucker, Staufenbiel, Brechtel, Walter, Multhaup, Penke, Adachi, Hartmann, Beyreuther, Garlanda, Bottazzi, Bastone, Mantovani, Vimr, Kalivoda, Deszo, Steenbergen, Malaviya, Navara, Uckun, Levine, Bernstein, Aronson, Schlienger, Cotte, Perfetto, Humphries, Ratto-Kim, Birx, Steffens, Landay, Carroll, June, Palmer, Burch, Davis, Herczyk, Howell, Reinsmoen, Schwartz, Thomas, Li, Kodama, Suzuki, Silverstein, El Khoury, Termeer, Benedix, Sleeman, Fieber, Voith, Ahrens, Miyake, Freudenberg, Galanos, Simon, Levy, García-Sastre,

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Disease relevance of Immunity, Natural

Delivery of the bacterial effector protein AvrRpt2 by Pseudomonas syringae specifically induces disease resistance in Arabidopsis plants expressing the RPS2 R protein [1].
These findings indicate that expansion of the peripheral T-cell pool mediated the increase in CD4 counts and suggest that approaches to reconstitute CD4 helper cell activity and decrease CCR5 expression may augment natural immunity to HIV infection [2].
Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria [3].
Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis [4].
Here we report that sHA induces maturation of DCs via the Toll-like receptor (TLR)-4, a receptor complex associated with innate immunity and host defense against bacterial infection [5].

Psychiatry related information on Immunity, Natural

The LPS receptor (CD14) links innate immunity with Alzheimer's disease [6].

High impact information on Immunity, Natural

After more than two decades of effort by researchers, IPCs finally claim their place in the hematopoietic chart as the most important cell type in antiviral innate immunity [7].
C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver [8].
TLR4 belongs to a family of innate immunity receptors that possess a large extracellular domain of leucine-rich repeats, a single trans-membrane segment, and a smaller cytoplasmic signaling region that engages the adaptor protein MyD88 [9].
The collectins, so named because they have in common an NH2-terminal collagen-like domain and a COOH-terminal lectin (carbohydrate binding) domain, are found in both lung and serum and participate in "innate" immunity, acting before induction of an antibody-mediated response [10].
Specific Bacterial Suppressors of MAMP Signaling Upstream of MAPKKK in Arabidopsis Innate Immunity [11].

Chemical compound and disease context of Immunity, Natural

Type I and II class A scavenger receptors (SR-AI/II) recognize a variety of polyanions including bacterial cell wall products such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), suggesting a role for SR-AI/II in innate immunity to bacterial infections [12].
In parallel with the effect of HC on the natural resistance of cats to FeLV, administration of silica before virus inoculation also markedly enhanced the FeLV susceptibility of adult cats [13].
Murine cytomegalovirus (MCMV) infection and the TLR3 ligand polyinosinic-polycytidylic acid [poly(I:C)] were used to activate innate immunity [14].
ALD1 is responsible for some of the elevated SA content and a majority of the disease resistance and dwarfism of agd2-1 [15].
PURPOSE: We report the results of a prospective trial in which patients with relapsing non-Hodgkin's lymphomas were sequentially treated with two regimens (mesna, ifosfamide, mitoxantrone, and etoposide [MINE], and etoposide, methylprednisolone, cytarabine, and cisplatin [ESHAP]) if they had no history of disease resistance to these drugs [16].

Biological context of Immunity, Natural

Our results demonstrate that LXR-dependent gene expression plays an unexpected role in innate immunity and suggest that common nuclear receptor pathways mediate macrophage responses to modified lipoproteins and intracellular pathogens [17].
Thus, SLPI/elastase act via PEPI/EPIs to operate a switch at the interface between innate immunity and wound healing [18].
These results reveal a novel role of DNA-PKcs in innate immune responses and a link between DNA repair and innate immunity [19].
These results indicated that CAD and DNase II work independently to degrade chromosomal DNA during apoptosis, and if the DNA is left undigested, it can activate the innate immunity in Drosophila [20].
Regulation of hematopoietic progenitor cell homeostasis is crucial for maintenance of innate immunity and the ability of the body to respond to injury and infection [21].

Anatomical context of Immunity, Natural

Here we show that Gfi1 is also expressed outside the lymphoid system in granulocytes and activated macrophages, cells that mediate innate immunity (that is, non-specific immunity) [22].
These findings indicate the essential function of the hepatocyte through NF-kappaB activation in certain systemic infections, possibly by coordinating innate immunity in the liver [23].
Our results uncover a specific role of MEF in the development and function of NK cells and in innate immunity [24].
Intestinal epithelial cells and innate immunity in the intestine: is CARD15/Nod2 another player [25]?
Localization of the MOS3-green fluorescent protein fusion to the nuclear envelope further indicates that MOS3 may encode a nucleoporin, suggesting that nuclear and cytoplasmic trafficking plays an important role in both R-gene-mediated and basal disease resistance [26].

Associations of Immunity, Natural with chemical compounds

Impaired mast cell-dependent natural immunity in complement C3-deficient mice [27].
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways [28].
An important function of host sialic acid is to regulate innate immunity, and microbes have evolved various strategies for subverting this process by decorating their surfaces with sialylated oligosaccharides that mimic those of the host [29].
The former bind mannose-, N-acetylglucosamine-, and fucose-terminating oligosaccharides, and may be important in innate immunity towards microbial pathogens, and in antigen trapping for processing and presentation in adaptive immunity [30].
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane [31].

Gene context of Immunity, Natural

The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats [32].
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease [33].
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection [34].
This report provides the first direct evidence that the ISG15 protease UBP43 and possibly protein ISGylation have a role in innate immunity against viral infection [34].
NDR1, a pathogen-induced component required for Arabidopsis disease resistance [35].

Analytical, diagnostic and therapeutic context of Immunity, Natural

Thus, understanding how STAT4 mediates pulmonary immune responses against bacterial pathogens will have important implications for the development of rational immunotherapy targeted at augmenting innate immunity [36].
Molecular cloning, induction and taxonomic distribution of caffeoyl-CoA 3-O-methyltransferase, an enzyme involved in disease resistance [37].
Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin [38].
Studies of IFN-deficient cells and animals derived by gene targeting have demonstrated the essential nature of IFN-mediated innate immunity [39].
Our results suggest activation of innate immunity in lung transplant recipients through TLR4 contributes to the development acute rejection after lung transplantation [40].

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