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Immunity, Natural

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  • After more than two decades of effort by researchers, IPCs finally claim their place in the hematopoietic chart as the most important cell type in antiviral innate immunity [7].
  • C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver [8].
  • TLR4 belongs to a family of innate immunity receptors that possess a large extracellular domain of leucine-rich repeats, a single trans-membrane segment, and a smaller cytoplasmic signaling region that engages the adaptor protein MyD88 [9].
  • The collectins, so named because they have in common an NH2-terminal collagen-like domain and a COOH-terminal lectin (carbohydrate binding) domain, are found in both lung and serum and participate in "innate" immunity, acting before induction of an antibody-mediated response [10].
  • Specific Bacterial Suppressors of MAMP Signaling Upstream of MAPKKK in Arabidopsis Innate Immunity [11].

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  2. Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Levine, B.L., Bernstein, W.B., Aronson, N.E., Schlienger, K., Cotte, J., Perfetto, S., Humphries, M.J., Ratto-Kim, S., Birx, D.L., Steffens, C., Landay, A., Carroll, R.G., June, C.H. Nat. Med. (2002) [Pubmed]
  3. Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria. Malaviya, R., Navara, C., Uckun, F.M. Immunity (2001) [Pubmed]
  4. Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. Fiorucci, S., Mencarelli, A., Palazzetti, B., Sprague, A.G., Distrutti, E., Morelli, A., Novobrantseva, T.I., Cirino, G., Koteliansky, V.E., de Fougerolles, A.R. Immunity (2002) [Pubmed]
  5. Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4. Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., Simon, J.C. J. Exp. Med. (2002) [Pubmed]
  6. The LPS receptor (CD14) links innate immunity with Alzheimer's disease. Fassbender, K., Walter, S., Kühl, S., Landmann, R., Ishii, K., Bertsch, T., Stalder, A.K., Muehlhauser, F., Liu, Y., Ulmer, A.J., Rivest, S., Lentschat, A., Gulbins, E., Jucker, M., Staufenbiel, M., Brechtel, K., Walter, J., Multhaup, G., Penke, B., Adachi, Y., Hartmann, T., Beyreuther, K. FASEB J. (2004) [Pubmed]
  7. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Liu, Y.J. Annu. Rev. Immunol. (2005) [Pubmed]
  8. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Garlanda, C., Bottazzi, B., Bastone, A., Mantovani, A. Annu. Rev. Immunol. (2005) [Pubmed]
  9. Lipopolysaccharide endotoxins. Raetz, C.R., Whitfield, C. Annu. Rev. Biochem. (2002) [Pubmed]
  10. Immunomodulatory functions of surfactant. Wright, J.R. Physiol. Rev. (1997) [Pubmed]
  11. Specific Bacterial Suppressors of MAMP Signaling Upstream of MAPKKK in Arabidopsis Innate Immunity. He, P., Shan, L., Lin, N.C., Martin, G.B., Kemmerling, B., Nürnberger, T., Sheen, J. Cell (2006) [Pubmed]
  12. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis. Thomas, C.A., Li, Y., Kodama, T., Suzuki, H., Silverstein, S.C., El Khoury, J. J. Exp. Med. (2000) [Pubmed]
  13. Determinants of susceptibility and resistance to feline leukemia virus infection. I. Role of macrophages. Hoover, E.A., Rojko, J.L., Wilson, P.L., Olsen, R.G. J. Natl. Cancer Inst. (1981) [Pubmed]
  14. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Sun, R., Gao, B. Gastroenterology (2004) [Pubmed]
  15. Divergent roles in Arabidopsis thaliana development and defense of two homologous genes, aberrant growth and death2 and AGD2-LIKE DEFENSE RESPONSE PROTEIN1, encoding novel aminotransferases. Song, J.T., Lu, H., Greenberg, J.T. Plant Cell (2004) [Pubmed]
  16. Results of a salvage treatment program for relapsing lymphoma: MINE consolidated with ESHAP. Rodriguez, M.A., Cabanillas, F.C., Velasquez, W., Hagemeister, F.B., McLaughlin, P., Swan, F., Romaguera, J.E. J. Clin. Oncol. (1995) [Pubmed]
  17. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Joseph, S.B., Bradley, M.N., Castrillo, A., Bruhn, K.W., Mak, P.A., Pei, L., Hogenesch, J., O'connell, R.M., Cheng, G., Saez, E., Miller, J.F., Tontonoz, P. Cell (2004) [Pubmed]
  18. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Zhu, J., Nathan, C., Jin, W., Sim, D., Ashcroft, G.S., Wahl, S.M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Wright, C.D., Ding, A. Cell (2002) [Pubmed]
  19. DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Chu, W., Gong, X., Li, Z., Takabayashi, K., Ouyang, H., Chen, Y., Lois, A., Chen, D.J., Li, G.C., Karin, M., Raz, E. Cell (2000) [Pubmed]
  20. Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation. Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., Nagata, S. Genes Dev. (2002) [Pubmed]
  21. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Broxmeyer, H.E., Bruns, H.A., Zhang, S., Cooper, S., Hangoc, G., McKenzie, A.N., Dent, A.L., Schindler, U., Naeger, L.K., Hoey, T., Kaplan, M.H. Immunity (2002) [Pubmed]
  22. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Karsunky, H., Zeng, H., Schmidt, T., Zevnik, B., Kluge, R., Schmid, K.W., Dührsen, U., Möröy, T. Nat. Genet. (2002) [Pubmed]
  23. High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation. Lavon, I., Goldberg, I., Amit, S., Landsman, L., Jung, S., Tsuberi, B.Z., Barshack, I., Kopolovic, J., Galun, E., Bujard, H., Ben-Neriah, Y. Nat. Med. (2000) [Pubmed]
  24. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Lacorazza, H.D., Miyazaki, Y., Di Cristofano, A., Deblasio, A., Hedvat, C., Zhang, J., Cordon-Cardo, C., Mao, S., Pandolfi, P.P., Nimer, S.D. Immunity (2002) [Pubmed]
  25. Intestinal epithelial cells and innate immunity in the intestine: is CARD15/Nod2 another player? Jobin, C. Gastroenterology (2003) [Pubmed]
  26. A putative nucleoporin 96 Is required for both basal defense and constitutive resistance responses mediated by suppressor of npr1-1,constitutive 1. Zhang, Y., Li, X. Plant Cell (2005) [Pubmed]
  27. Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Prodeus, A.P., Zhou, X., Maurer, M., Galli, S.J., Carroll, M.C. Nature (1997) [Pubmed]
  28. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Björkbacka, H., Kunjathoor, V.V., Moore, K.J., Koehn, S., Ordija, C.M., Lee, M.A., Means, T., Halmen, K., Luster, A.D., Golenbock, D.T., Freeman, M.W. Nat. Med. (2004) [Pubmed]
  29. Diversity of microbial sialic acid metabolism. Vimr, E.R., Kalivoda, K.A., Deszo, E.L., Steenbergen, S.M. Microbiol. Mol. Biol. Rev. (2004) [Pubmed]
  30. The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin. Leteux, C., Chai, W., Loveless, R.W., Yuen, C.T., Uhlin-Hansen, L., Combarnous, Y., Jankovic, M., Maric, S.C., Misulovin, Z., Nussenzweig, M.C., Feizi, T. J. Exp. Med. (2000) [Pubmed]
  31. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. Jabado, N., Jankowski, A., Dougaparsad, S., Picard, V., Grinstein, S., Gros, P. J. Exp. Med. (2000) [Pubmed]
  32. The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site and leucine-rich repeats. Mindrinos, M., Katagiri, F., Yu, G.L., Ausubel, F.M. Cell (1994) [Pubmed]
  33. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Durbin, J.E., Hackenmiller, R., Simon, M.C., Levy, D.E. Cell (1996) [Pubmed]
  34. Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Ritchie, K.J., Hahn, C.S., Kim, K.I., Yan, M., Rosario, D., Li, L., de la Torre, J.C., Zhang, D.E. Nat. Med. (2004) [Pubmed]
  35. NDR1, a pathogen-induced component required for Arabidopsis disease resistance. Century, K.S., Shapiro, A.D., Repetti, P.P., Dahlbeck, D., Holub, E., Staskawicz, B.J. Science (1997) [Pubmed]
  36. STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection. Deng, J.C., Zeng, X., Newstead, M., Moore, T.A., Tsai, W.C., Thannickal, V.J., Standiford, T.J. J. Immunol. (2004) [Pubmed]
  37. Molecular cloning, induction and taxonomic distribution of caffeoyl-CoA 3-O-methyltransferase, an enzyme involved in disease resistance. Schmitt, D., Pakusch, A.E., Matern, U. J. Biol. Chem. (1991) [Pubmed]
  38. Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin. Applequist, S.E., Rollman, E., Wareing, M.D., Lidén, M., Rozell, B., Hinkula, J., Ljunggren, H.G. J. Immunol. (2005) [Pubmed]
  39. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Levy, D.E., García-Sastre, A. Cytokine Growth Factor Rev. (2001) [Pubmed]
  40. The role of innate immunity in acute allograft rejection after lung transplantation. Palmer, S.M., Burch, L.H., Davis, R.D., Herczyk, W.F., Howell, D.N., Reinsmoen, N.L., Schwartz, D.A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
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