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Gene Review

FOXK1  -  forkhead box K1

Homo sapiens

Synonyms: Forkhead box protein K1, IMAGE:5164497, MNF, Myocyte nuclear factor
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High impact information on FOXK1

  • The in silico expression analysis showed FOXK1 expression in immature tissues of brain, eye, heart, lung and thymus [1].
  • In adults, FOXK1 was predominantly expressed in many malignant tissues, in particular in the tumors of brain, colon and lymph node [1].
  • Human FOXK1 (733 aa) showed 88.7% total amino-acid identity with mouse Foxk1 (719 aa), 48.7% total amino-acid identity with human FOXK2, and 47.5% total amino-acid identity with Xenopus Foxk2 [2].
  • Here, we identified and characterized the human FOXK1 gene by using bioinformatics [2].
  • FOXK1 gene, consisting of nine exons, was mapped to human chromosome 7p22 [2].

Other interactions of FOXK1

  • Forkhead associated (FHA) domain and FOX domain were conserved among human FOXK1, FOXK2, mouse FoxK1, and Xenopus Foxk2 [2].


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