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Gene Review:

LNX2 - ligand of numb-protein X 2

Homo sapiens

Synonyms: Ligand of Numb protein X 2, MGC46315, Numb-binding protein 2, PDZ domain-containing RING finger protein 1, PDZRN1

Katoh, M. et al., Mirza, M. et al., Rice, D.S. et al.

Katoh, Katoh,

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Disease relevance of LNX2

The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2) [1].

High impact information on LNX2

LNX is the paralog of PDZRN1 (PDZ domain containing RING finger 1) [2].

Analytical, diagnostic and therapeutic context of LNX2

CAR and LNX2 protein expression in embryonic mouse tissues was analyzed by immunohistochemistry [1].
In situ hybridization analysis revealed complementary patterns of Lnx1 and Lnx2 expression in developing and adult brain, although in several structures they are present in the same cell populations [3].

References

The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2). Mirza, M., Raschperger, E., Philipson, L., Pettersson, R.F., Sollerbrant, K. Exp. Cell Res. (2005) [Pubmed]
Identification and characterization of PDZRN3 and PDZRN4 genes in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2004) [Pubmed]
The Lnx family proteins function as molecular scaffolds for Numb family proteins. Rice, D.S., Northcutt, G.M., Kurschner, C. Mol. Cell. Neurosci. (2001) [Pubmed]

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LNX2	Bos taurus
LNX2	Canis lupus familiaris
lnx2a	Danio rerio
LNX2	Gallus gallus
LNX2	Macaca mulatta
Lnx2	Mus musculus
LNX2	Pan troglodytes
Lnx2	Rattus norvegicus
lnx2	Xenopus (Silurana) tropicalis

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