The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SEC31A  -  SEC31 homolog A (S. cerevisiae)

Homo sapiens

Synonyms: ABP125, ABP130, HSPC275, HSPC334, KIAA0905, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SEC31A

  • In the short, type II, transcript nt 2670 of SEC31L1 was fused in-frame to nt 4080 of ALK [1].
  • In the present study, we describe the finding of a novel SEC31L1/ALK fusion gene in an intraabdominal IMT of a young man [1].
  • Among the downregulated genes, K-5/46 and K-45 were 99% identical to the og24d08.s1 cDNA clone and to mitochondrial genes for tRNAs and 12S and 16S ribosomal RNAs, respectively, while K-50 was 100% identical to KIAA0905 protein [2].

Analytical, diagnostic and therapeutic context of SEC31A

  • Sequence analysis showed that the fragment was a hybrid cDNA product in which nt 3012 of SEC31L1 (NM_016211), located in band 4q21, was fused in-frame to nt 4080 of ALK (NM_004304) [1].
  • Genomic PCR and subsequent sequencing showed that the breakpoints were located in intron 23 of SEC31L1 and intron 20 of ALK [1].


  1. Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor. Panagopoulos, I., Nilsson, T., Domanski, H.A., Isaksson, M., Lindblom, P., Mertens, F., Mandahl, N. Int. J. Cancer (2006) [Pubmed]
  2. Identification and isolation of differentially expressed genes in osmotically stressed human oral keratinocytes. Kim, J.H., Hong, J.A., Pih, K.T., Hwang, I. Arch. Oral Biol. (2001) [Pubmed]
WikiGenes - Universities