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Gene Review:

DOPEY1 - dopey family member 1

Homo sapiens

Synonyms: KIAA1117, Protein dopey-1, dJ202D23.2

Rachidi, M. et al., Pascon, R.C. et al.

Rachidi, Lopes, Costantine, Delabar,

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Disease relevance of DOPEY1

C21orf5, a new member of dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in down syndrome [1].

Psychiatry related information on DOPEY1

Considering together our and previous findings, we suggest that the human dopey family member, C21orf5, could play a role in brain morphogenesis and, when overexpressed, it could participate in neurological features and mental retardation observed in DS patients [1].

High impact information on DOPEY1

Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans [2].

Associations of DOPEY1 with chemical compounds

To elucidate C21orf5 molecular function, we performed a comparative study of protein sequences in several species and showed that C21orf5 represents a new member of the Dopey leucine zipper-like family [1].

References

C21orf5, a new member of dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in down syndrome. Rachidi, M., Lopes, C., Costantine, M., Delabar, J.M. DNA Res. (2005) [Pubmed]
Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. Pascon, R.C., Miller, B.L. Mol. Microbiol. (2000) [Pubmed]

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AgaP_AGAP007605	Anopheles gambiae str. PEST
DOPEY1	Bos taurus
DOPEY1	Canis lupus familiaris
dopey1	Danio rerio
CG15099	Drosophila melanogaster
DOPEY1	Gallus gallus
DOPEY1	Macaca mulatta
Dopey1	Mus musculus
DOPEY1	Pan troglodytes
Dopey1	Rattus norvegicus
dopey1	Xenopus (Silurana) tropicalis

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