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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tardbp  -  TAR DNA binding protein

Mus musculus

Synonyms: 1190002A23Rik, C85084, TAR DNA-binding protein 43, TDP-43, Tdp43
 
 
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High impact information on Tardbp

  • Taken together, our results demonstrate that 5'-GTGTGT motifs on the complementary strand are required to prevent premature expression of SP-10 during spermatogenesis and implicate TDP-43 as the putative regulatory factor [1].
  • Further, Northern analysis and immunohistochemistry of mouse testis showed the presence of TDP-43 in cell-types where the SP-10 gene remains repressed [1].
  • With DNA transfection assay, we have established the importance of the glycine-rich domain for the exon-skipping activity of TDP-43 [2].
  • Interestingly, combined database analysis and cDNA cloning have demonstrated that the primary transcript of the mammalian TDP genes undergoes alternative splicing to generate 11 mRNAs, including the one encoding TDP-43 [2].

References

  1. cis-requirement for the maintenance of round spermatid-specific transcription. Acharya, K.K., Govind, C.K., Shore, A.N., Stoler, M.H., Reddi, P.P. Dev. Biol. (2006) [Pubmed]
  2. Structural diversity and functional implications of the eukaryotic TDP gene family. Wang, H.Y., Wang, I.F., Bose, J., Shen, C.K. Genomics (2004) [Pubmed]
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