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Gene Review

Fbxw8  -  F-box and WD-40 domain protein 8

Mus musculus

Synonyms: 4930438M06Rik, F-box and WD-40 domain-containing protein 8, F-box/WD repeat-containing protein 8, FBW6, FBW8, ...
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Disease relevance of Fbxw8

  • Fbxw8-/- embryos show intrauterine growth retardation and abnormal development of the placenta, characterized by both a reduced thickness of the spongiotrophoblast layer and abnormal vessel structure in the labyrinth layer [1].

High impact information on Fbxw8


  1. Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Tsunematsu, R., Nishiyama, M., Kotoshiba, S., Saiga, T., Kamura, T., Nakayama, K.I. Mol. Cell. Biol. (2006) [Pubmed]
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