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Gene Review:

FBXW8 - F-box and WD repeat domain containing 8

Homo sapiens

Synonyms: F-box and WD-40 domain-containing protein 8, F-box only protein 29, F-box/WD repeat-containing protein 8, FBW6, FBW8, ...

Huber, C. et al., Okabe, H. et al.

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High impact information on FBXW8

Using deletion analysis, we found that CUL7 uses its central region to interact with the Skp1-Fbx29 heterodimer [1].
A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation [2].
This is mediated by phosphorylation at Thr286 through the activity of the Ras/Raf/MEK/ERK cascade and the F-box protein FBXW8, which is an E3 ligase [2].
Depletion of FBXW8 caused a significant accumulation of cyclin D1, as well as sequestration of CDK1 in the cytoplasm [2].
Thus, FBXW8 plays an essential role in cancer cell proliferation through proteolysis of cyclin D1 [2].

Regulatory relationships of FBXW8

The majority of FBXW8 is expressed in the cytoplasm during G1 and S phase [2].

References

Identification of mutations in CUL7 in 3-M syndrome. Huber, C., Dias-Santagata, D., Glaser, A., O'Sullivan, J., Brauner, R., Wu, K., Xu, X., Pearce, K., Wang, R., Uzielli, M.L., Dagoneau, N., Chemaitilly, W., Superti-Furga, A., Dos Santos, H., Mégarbané, A., Morin, G., Gillessen-Kaesbach, G., Hennekam, R., Van der Burgt, I., Black, G.C., Clayton, P.E., Read, A., Le Merrer, M., Scambler, P.J., Munnich, A., Pan, Z.Q., Winter, R., Cormier-Daire, V. Nat. Genet. (2005) [Pubmed]
A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation. Okabe, H., Lee, S.H., Phuchareon, J., Albertson, D.G., McCormick, F., Tetsu, O. PLoS ONE (2006) [Pubmed]

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FBXW8	Bos taurus
RNFT2	Canis lupus familiaris
fbxw8	Danio rerio
FBXW8	Gallus gallus
FBXW8	Macaca mulatta
Fbxw8	Mus musculus
FBXW8	Pan troglodytes
Fbxw8	Rattus norvegicus
fbxw8	Xenopus (Silurana) tropicalis

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