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Gene Review

FBXW8  -  F-box and WD repeat domain containing 8

Homo sapiens

Synonyms: F-box and WD-40 domain-containing protein 8, F-box only protein 29, F-box/WD repeat-containing protein 8, FBW6, FBW8, ...
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High impact information on FBXW8


Regulatory relationships of FBXW8

  • The majority of FBXW8 is expressed in the cytoplasm during G1 and S phase [2].


  1. Identification of mutations in CUL7 in 3-M syndrome. Huber, C., Dias-Santagata, D., Glaser, A., O'Sullivan, J., Brauner, R., Wu, K., Xu, X., Pearce, K., Wang, R., Uzielli, M.L., Dagoneau, N., Chemaitilly, W., Superti-Furga, A., Dos Santos, H., Mégarbané, A., Morin, G., Gillessen-Kaesbach, G., Hennekam, R., Van der Burgt, I., Black, G.C., Clayton, P.E., Read, A., Le Merrer, M., Scambler, P.J., Munnich, A., Pan, Z.Q., Winter, R., Cormier-Daire, V. Nat. Genet. (2005) [Pubmed]
  2. A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation. Okabe, H., Lee, S.H., Phuchareon, J., Albertson, D.G., McCormick, F., Tetsu, O. PLoS ONE (2006) [Pubmed]
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