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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NUP160  -  nucleoporin 160kDa

Homo sapiens

Synonyms: 160 kDa nucleoporin, FLJ22583, KIAA0197, NUP120, Nuclear pore complex protein Nup160, ...
 
 
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High impact information on NUP160

  • The mammalian nucleoporin (Nup)-107 is part of a hetero-oligomeric complex, that also contains Nup160, Nup133, Nup96, and the mammalian homolog of yeast Sec13p [1].
  • Nup98 was previously described to interact with the nuclear-oriented Nup160, 133, 107, 96 complex through direct binding to Nup96 [2].
  • Finally, nuclear export of the NES reporter protein was significantly inhibited in cells in which nuclear export of mRNAs had been specifically blocked by microinjection of anti-TAP antibodies or by expression of a dominant negative form of NUP160 [3].

References

  1. Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex. Boehmer, T., Enninga, J., Dales, S., Blobel, G., Zhong, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes. Griffis, E.R., Xu, S., Powers, M.A. Mol. Biol. Cell (2003) [Pubmed]
  3. Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs. O'Hagan, H.M., Ljungman, M. Exp. Cell Res. (2004) [Pubmed]
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