Gene Review:
NUP98 - nucleoporin 98kDa
Homo sapiens
Synonyms:
ADAR2, ADIR2, NUP196, NUP96, Nuclear pore complex protein Nup98-Nup96
Romana,
Radford-Weiss,
Ben Abdelali,
Schluth,
Petit,
Dastugue,
Talmant,
Bilhou-Nabera,
Mugneret,
Lafage-Pochitaloff,
Mozziconacci,
Andrieu,
Lai,
Terre,
Rack,
Cornillet-Lefebvre,
Luquet,
Nadal,
Nguyen-Khac,
Perot,
Van den Akker,
Fert-Ferrer,
Cabrol,
Charrin,
Tigaud,
Poirel,
Vekemans,
Bernard,
Berger,
Nakamura,
Yamazaki,
Hatano,
Miura,
Jaju,
Fidler,
Haas,
Strickson,
Watkins,
Clark,
Cross,
Cheng,
Aplan,
Kearney,
Boultwood,
Wainscoat,
Hodel,
Hodel,
Griffis,
Hennig,
Ratner,
Xu,
Powers,
Panagopoulos,
Isaksson,
Billström,
Strömbeck,
Mitelman,
Johansson,
Liu,
Chen,
Cui,
Wu,
He,
Chen,
Zhou,
Ahuja,
Hong,
Aplan,
Tcheurekdjian,
Forman,
Slovak,
- A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia. Jaju, R.J., Fidler, C., Haas, O.A., Strickson, A.J., Watkins, F., Clark, K., Cross, N.C., Cheng, J.F., Aplan, P.D., Kearney, L., Boultwood, J., Wainscoat, J.S. Blood (2001)
- The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion. Ahuja, H.G., Felix, C.A., Aplan, P.D. Blood (1999)
- NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). Nakamura, T., Yamazaki, Y., Hatano, Y., Miura, I. Blood (1999)
- The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15). Taketani, T., Taki, T., Shibuya, N., Ito, E., Kitazawa, J., Terui, K., Hayashi, Y. Cancer Res. (2002)
- Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nakamura, T., Largaespada, D.A., Lee, M.P., Johnson, L.A., Ohyashiki, K., Toyama, K., Chen, S.J., Willman, C.L., Chen, I.M., Feinberg, A.P., Jenkins, N.A., Copeland, N.G., Shaughnessy, J.D. Nat. Genet. (1996)
- The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Borrow, J., Shearman, A.M., Stanton, V.P., Becher, R., Collins, T., Williams, A.J., Dubé, I., Katz, F., Kwong, Y.L., Morris, C., Ohyashiki, K., Toyama, K., Rowley, J., Housman, D.E. Nat. Genet. (1996)
- The three-dimensional structure of the autoproteolytic, nuclear pore-targeting domain of the human nucleoporin Nup98. Hodel, A.E., Hodel, M.R., Griffis, E.R., Hennig, K.A., Ratner, G.A., Xu, S., Powers, M.A. Mol. Cell (2002)
- Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. von Kobbe C, n.u.l.l., van Deursen JM, n.u.l.l., Rodrigues, J.P., Sitterlin, D., Bachi, A., Wu, X., Wilm, M., Carmo-Fonseca, M., Izaurralde, E. Mol. Cell (2000)
- Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia. Yamamoto, M., Kakihana, K., Kurosu, T., Murakami, N., Miura, O. Cancer Genet. Cytogenet. (2005)
- Role of nucleoporin induction in releasing an mRNA nuclear export block. Enninga, J., Levy, D.E., Blobel, G., Fontoura, B.M. Science (2002)
- Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function. Wu, X., Kasper, L.H., Mantcheva, R.T., Mantchev, G.T., Springett, M.J., van Deursen, J.M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Kasper, L.H., Brindle, P.K., Schnabel, C.A., Pritchard, C.E., Cleary, M.L., van Deursen, J.M. Mol. Cell. Biol. (1999)
- Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. Iwasaki, M., Kuwata, T., Yamazaki, Y., Jenkins, N.A., Copeland, N.G., Osato, M., Ito, Y., Kroon, E., Sauvageau, G., Nakamura, T. Blood (2005)
- The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. Arai, Y., Hosoda, F., Kobayashi, H., Arai, K., Hayashi, Y., Kamada, N., Kaneko, Y., Ohki, M. Blood (1997)
- NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique. Romana, S.P., Radford-Weiss, I., Ben Abdelali, R., Schluth, C., Petit, A., Dastugue, N., Talmant, P., Bilhou-Nabera, C., Mugneret, F., Lafage-Pochitaloff, M., Mozziconacci, M.J., Andrieu, J., Lai, J.L., Terre, C., Rack, K., Cornillet-Lefebvre, P., Luquet, I., Nadal, N., Nguyen-Khac, F., Perot, C., Van den Akker, J., Fert-Ferrer, S., Cabrol, C., Charrin, C., Tigaud, I., Poirel, H., Vekemans, M., Bernard, O.A., Berger, R. Leukemia (2006)
- Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA. Pineault, N., Abramovich, C., Humphries, R.K. Leukemia (2005)
- NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15). Lahortiga, I., Vizmanos, J.L., Agirre, X., Vázquez, I., Cigudosa, J.C., Larrayoz, M.J., Sala, F., Gorosquieta, A., Perez-Equiza, K., Calasanz, M.J., Odero, M.D. Cancer Res. (2003)
- Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13). Taketani, T., Taki, T., Shibuya, N., Kikuchi, A., Hanada, R., Hayashi, Y. Cancer Res. (2002)
- Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes. Griffis, E.R., Xu, S., Powers, M.A. Mol. Biol. Cell (2003)
- The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR. Fontoura, B.M., Dales, S., Blobel, G., Zhong, H. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Nuclear export assays for poly(A) RNAs. Chakraborty, P., Satterly, N., Fontoura, B.M. Methods (2006)
- Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Bonifaci, N., Moroianu, J., Radu, A., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1997)
- NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Gurevich, R.M., Aplan, P.D., Humphries, R.K. Blood (2004)
- Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro. Liu, H.L., Chen, Y., Cui, G.H., Wu, Q.L., He, J., Chen, W.H., Zhou, J.F. Acta Pharmacol. Sin. (2005)
- Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. Zolotukhin, A.S., Felber, B.K. J. Virol. (1999)
- Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13). Panagopoulos, I., Isaksson, M., Billström, R., Strömbeck, B., Mitelman, F., Johansson, B. Genes Chromosomes Cancer (2003)
- The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9. Taketani, T., Taki, T., Ono, R., Kobayashi, Y., Ida, K., Hayashi, Y. Genes Chromosomes Cancer (2002)
- Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). Fujino, T., Suzuki, A., Ito, Y., Ohyashiki, K., Hatano, Y., Miura, I., Nakamura, T. Blood (2002)
- t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF). Ahuja, H.G., Hong, J., Aplan, P.D., Tcheurekdjian, L., Forman, S.J., Slovak, M.L. Cancer Res. (2000)
- 11p15 translocations involving the NUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome. Nishiyama, M., Arai, Y., Tsunematsu, Y., Kobayashi, H., Asami, K., Yabe, M., Kato, S., Oda, M., Eguchi, H., Ohki, M., Kaneko, Y. Genes Chromosomes Cancer (1999)