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Gene Review

NUP133  -  nucleoporin 133kDa

Homo sapiens

Synonyms: 133 kDa nucleoporin, FLJ10814, Nuclear pore complex protein Nup133, Nucleoporin Nup133
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High impact information on NUP133

  • Partial in vivo depletion of Nup133 or Nup107 via RNAi in HeLa cells resulted in reduced levels of multiple nucleoporins and decreased NPC density in the NE [1].
  • Here, we immunodeplete a single subunit, the Nup107-160 complex, using antibodies to Nup85 and Nup133, two of its components [2].
  • Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex [3].
  • Here, we explore the domain structure of Nup133, a nucleoporin in a conserved NPC subcomplex that is crucial for NPC biogenesis and is believed to form part of the NPC scaffold [3].
  • We show that human Nup133 contains two domains: a COOH-terminal domain responsible for its interaction with its subcomplex through Nup107; and an NH2-terminal domain whose crystal structure reveals a seven-bladed beta-propeller [3].

Other interactions of NUP133

  • The mammalian nucleoporin (Nup)-107 is part of a hetero-oligomeric complex, that also contains Nup160, Nup133, Nup96, and the mammalian homolog of yeast Sec13p [4].


  1. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Walther, T.C., Alves, A., Pickersgill, H., Loïodice, I., Hetzer, M., Galy, V., Hülsmann, B.B., Köcher, T., Wilm, M., Allen, T., Mattaj, I.W., Doye, V. Cell (2003) [Pubmed]
  2. Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. Harel, A., Orjalo, A.V., Vincent, T., Lachish-Zalait, A., Vasu, S., Shah, S., Zimmerman, E., Elbaum, M., Forbes, D.J. Mol. Cell (2003) [Pubmed]
  3. Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex. Berke, I.C., Boehmer, T., Blobel, G., Schwartz, T.U. J. Cell Biol. (2004) [Pubmed]
  4. Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex. Boehmer, T., Enninga, J., Dales, S., Blobel, G., Zhong, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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