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Gene Review:

ATMIN - ATM interactor

Homo sapiens

Synonyms: ASCIZ, ATM/ATR-substrate CHK2-interacting zinc finger protein, KIAA0431, ZNF822, Zinc finger protein 822

McNees, C.J. et al.

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High impact information on ASCIZ

ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage [1].
ASCIZ focus formation and increased apoptosis in ASCIZ-depleted cells depend on the mismatch repair protein MLH1 [1].
Interestingly, ASCIZ foci form efficiently during G1 phase, when sister chromatids are unavailable as recombination templates [1].

Biological context of ASCIZ

ASCIZ depletion dramatically increases apoptosis after methylating DNA damage and impairs Rad51 focus formation in response to methylating agents but not after ionizing radiation [1].

Other interactions of ASCIZ

Here we report a novel human SQ/TQ cluster domain-containing protein termed ASCIZ that forms Rad51-containing foci in response to base-modifying DNA methylating agents but not in response to DSB-inducing agents [1].

References

ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage. McNees, C.J., Conlan, L.A., Tenis, N., Heierhorst, J. EMBO J. (2005) [Pubmed]

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