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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ESYT1  -  extended synaptotagmin-like protein 1

Homo sapiens

Synonyms: E-Syt1, Extended synaptotagmin-1, FAM62A, KIAA0747, MBC2, ...
 
 
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Disease relevance of FAM62A

 

High impact information on FAM62A

  • The scatchard plots were curvilinear and composed of a high-affinity binding site with Ka1 3.4 +/- 0.7 x 10(9) L.mol-1 and maximal binding capacity (MBC) MBC1 57.0 +/- 11.9 fmol/mg DNA and a low-affinity binding site with Ka2 2.9 +/- 1.1 x 10(8) L.mol-1 and MBC2 124.7 +/- 22.1 fmol/mg DNA (n = 6) [2].
  • However, the number of sites per nuclei was small compared to tadpole; expressed as pmol/mg DNA, the maximum binding capacity of the high affinity set of sites (MBC1) was 2.2 +/- 0.31 versus 12.9 +/- 1.80 and MBC2 was 24.9 +/- 4.5 versus 42.2 +/- 54 [3].

References

  1. Comparative in-vitro activity of sparfloxacin against genital pathogens. Perea, E.J., Aznar, J., Garcia-Iglesias, M.C., Pascual, A. J. Antimicrob. Chemother. (1996) [Pubmed]
  2. Triiodothyronine (T3)-associated upregulation and downregulation of nuclear T3 binding in the human fibroblast cell (MRC-5)--stimulation of malic enzyme, glucose-6-phosphate-dehydrogenase, and 6-phosphogluconate-dehydrogenase by insulin, but not by T3. Matzen, L.E., Kristensen, S.R., Kvetny, J. Metab. Clin. Exp. (1991) [Pubmed]
  3. 3,5,3'-Triiodothyronine receptors and thyroxine 5'-monodeiodinating activity in thyroid hormone-insensitive amphibia. Galton, V.A. Gen. Comp. Endocrinol. (1985) [Pubmed]
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